Results 191 to 200 of about 8,404 (278)

EnzRetro: Enzymatic Retrosynthetic Planning With Site-Specific Reaction Edits Based on Sequence Generative Architecture. [PDF]

Exploration (Beijing)
Cao Y, Chen H, Zhang T, Zhao X, Li B, Zheng X.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Diastereoselective Cyclopropanation with Secondary Diazoacetamides to Access <i>endo</i>-Azabicyclo[3.1.0]hexane-6-carboxamides. [PDF]

Org Lett
Nguyen TH, Saito T, Chang W, Navarro A, Davies HML.   +4 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

¹⁹F NMR Interpretation Complications with 3-Bromo-1,1,1-Trifluoroacetone (BTFA) and an Alternative 2-Iodo-<i>N</i>-(2,2,2-Trifluoroethyl)acetamide (ITFEA) ¹⁹F NMR Probe. [PDF]

Anal Chem
Norman SM, Xu J, Yoon L, Rhoades D, Cheng M, Kelly JW.   +5 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Genetic Ancestry and Population Structure Across Ecuador. [PDF]

Genes (Basel)
González-Andrade F.
europepmc   +1 more source

Vibration analysis by substructure synthesis method. Part 7. Composition of transfer function synthesis method and transfer function dividing method.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C, 1988
Sok-chu, PARK, OKUMA, Masaaki, NAGAMATSU, Akio   +2 more
openaire   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Drinking Water Treatment Using PES/ZnO Mixed Matrix Membranes: Enhanced Antifouling Performance and Rejection at Low Nanoparticle Loadings. [PDF]

ACS Omega
Silva VB, Mierzwa JC, de Oliveira GB, Deda DK, de Castro KC, Subtil EL.   +5 more
europepmc   +1 more source