Results 291 to 300 of about 40,678 (327)
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2010
Publisher Summary This chapter provides an overview of the functional properties of the subthalamic nucleus (STN) and describes recent insights in its role in normal and pathological brain processes, with emphasis on Parkinson's disease (PD) and epileptic disorders.
Stéphane Charpier +4 more
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Publisher Summary This chapter provides an overview of the functional properties of the subthalamic nucleus (STN) and describes recent insights in its role in normal and pathological brain processes, with emphasis on Parkinson's disease (PD) and epileptic disorders.
Stéphane Charpier +4 more
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GABAergic interneurons in human subthalamic nucleus
Movement Disorders, 2005AbstractThe subthalamic nucleus (STN) is considered a homogeneous structure composed essentially of projection neurons that exert a profound glutamate‐mediated excitatory influence upon the main output structures of the basal ganglia. It is currently the most efficient target for deep brain stimulations designed to alleviate symptoms of Parkinson's ...
Julie-Christine Lévesque, André Parent
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2016
The glutamatergic subthalamic nucleus (STN) is a key node in the cortico-basal ganglia-thalamo-cortical circuit. As a component of the hyperdirect and indirect pathways, the STN is important for constraining movement, thought, and emotion through synaptic excitation of GABAergic basal ganglia output neurons.
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The glutamatergic subthalamic nucleus (STN) is a key node in the cortico-basal ganglia-thalamo-cortical circuit. As a component of the hyperdirect and indirect pathways, the STN is important for constraining movement, thought, and emotion through synaptic excitation of GABAergic basal ganglia output neurons.
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Genetics of subthalamic nucleus in development and disease
Experimental Neurology, 2005The subthalamic nucleus (STN) is a crucial node in the basal ganglia. Clinical success in targeting the STN for deep brain stimulation in Parkinson's disease patients has prompted increased interest in understanding STN biology. In this report, we discuss recent evidence for transcription factor mediated regulation of STN development.
Steven T. Philips +2 more
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NeuroReport, 1996
Several brain sites are important for seizure control, including the area tempestas, superior colliculus, thalamus and substantia nigra. These sites are especially sensitive to changes in GABAergic transmission achieved by localized infusions of GABAergic agents.
Jana Velíšková +3 more
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Several brain sites are important for seizure control, including the area tempestas, superior colliculus, thalamus and substantia nigra. These sites are especially sensitive to changes in GABAergic transmission achieved by localized infusions of GABAergic agents.
Jana Velíšková +3 more
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The Subthalamic Nucleus and Tremor in Parkinson's Disease
Movement Disorders, 2008The role of the subthalamic nucleus (STN) in the origin of parkinsonian tremor is discussed. Previous studies in monkeys made parkinsonian by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) administration suggested a direct participation of the STN in the pathophysiology of tremor.
J. Vitek +7 more
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Roles of the subthalamic nucleus and subthalamic HCN channels in absence seizures
Journal of Neurophysiology, 2012Absence seizures consist of a brief and sudden impairment of consciousness. They are characterized by bilaterally synchronized spike and wave discharges (SWDs), which reflect abnormal oscillations in the thalamocortical loops. Recent studies have suggested that the basal ganglia are involved in generation of the SWDs, but their roles are poorly ...
Tsuyoshi Inoue +2 more
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Neuroscience Letters, 2009
High frequency stimulation (HFS) of the subthalamic nucleus (STN) is an effective treatment of idiopathic Parkinson disease (PD). Exactly how HFS works remains unclear. Although HFS of the STN is most effective in improving contralateral motor functions, clinical studies have shown bilateral beneficial effects suggesting that unilateral STN HFS affects
Joshua A. Klemp +5 more
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High frequency stimulation (HFS) of the subthalamic nucleus (STN) is an effective treatment of idiopathic Parkinson disease (PD). Exactly how HFS works remains unclear. Although HFS of the STN is most effective in improving contralateral motor functions, clinical studies have shown bilateral beneficial effects suggesting that unilateral STN HFS affects
Joshua A. Klemp +5 more
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Jules Bernard Luys and the subthalamic nucleus
Movement Disorders, 2002AbstractJules Bernard Luys, a highly energetic French investigator who made important contributions to anatomopathology, clinical neurology, and psychiatry, discovered the subthalamic nucleus in 1865. Unfortunately, Luys’ description of the nucleus that still bears his name, as well as his highly original insights on the role of this important motor ...
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A golgi study on the subthalamic nucleus of the cat
Journal of Comparative Neurology, 1978AbstractThe subthalamic nucleus (ST) of kittens was studied by means of the rapid Golgi silver impregnation method.The neurons of the ST were classified into three types. Type I neurons, the main constituents of the ST, had oval or polygonal cell bodies with a mean diameter of 26 μm by 36 μm and four to six primary dendrites.
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