Results 291 to 300 of about 489,147 (319)
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Subthalamic nucleus stimulation in Parkinson’s disease

Neurological Sciences, 2008
Deep brain stimulation (DBS) is an effective surgical treatment for advanced Parkinson's disease (PD), with significant advantages in morbidity-mortality and quality of life when compared to lesion techniques such as thalamotomy and/or pallidotomy. The procedure is indicated in patients with severe resting tremor, unresponsive to conventional medical ...
Marconi, Roberto   +2 more
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Subthalamic Nucleus

2015
Fue en 1865 cuando Jules Bernard Luys, un neurólogo francés, describió por primera vez una estructura gris de forma biconvexa, ubicada bilateralmente en la unión diencéfalo-mesencefálica y con una participación esencial en el control de los movimientos, a la que luego se le asignaron funciones adicionales en los procesos límbicos y cognitivos.
Fabián Piedimonte, Tania Acosta
openaire   +1 more source

Neurophysiological Refinement of Subthalamic Nucleus Targeting

Neurosurgery, 2002
ABSTRACT OBJECTIVE Advances in image-guided stereotactic surgery, microelectrode recording techniques, and stimulation technology have been the driving forces behind a resurgence in the use of functional neurosurgery for the treatment of movement disorders.
Alon Y. Mogilner   +6 more
openaire   +3 more sources

Models of the subthalamic nucleus

Medical Engineering & Physics, 2004
A coherent set of models is presented that provide novel and testable predictions about the functional role of the subthalamic nucleus (STN) in the basal ganglia. The STN is emerging as an important target for novel therapeutic strategies for the alleviation of Parkinsonian type symptoms [Lancet 345 (1995) 91; Science 249 (1990) 1436].
David Willshaw, Andrew Gillies
openaire   +3 more sources

The microanatomical environment of the subthalamic nucleus [PDF]

open access: possibleJournal of Neurosurgery, 2007
✓High-frequency stimulation of the subthalamic nucleus (STN) is a widely performed method to treat advanced Parkinson disease. Due to the limitations of current imaging techniques, the 3D microanatomy of the STN and its surrounding structures in the mesencephalon are not well known.
Yasin Temel   +7 more
openaire   +2 more sources

Subthalamic nucleus deep brain stimulation in isolated dystonia

Neurology, 2016
Objective: To report long-term safety and efficacy outcomes of a large cohort of patients with medically refractory isolated dystonia treated with subthalamic nucleus (STN) deep brain stimulation (DBS).
J. Ostrem   +9 more
semanticscholar   +1 more source

Somatotopic Localization in Rhesus Subthalamic Nucleus

Archives of Neurology, 1962
In 1947, Mettler and Whittier 1 were able to produce abnormal bodily movements in monkeys by placing lesions in the subthalamic nucleus. These movements, occurring for the most part in the limbs, closely resembled those seen in ballism (flinging movements) or, more broadly, chorea ("dancing" movements).
Fred A. Mettler, Gerald M. Stern
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The Subthalamic Nucleus

2010
Publisher Summary This chapter provides an overview of the functional properties of the subthalamic nucleus (STN) and describes recent insights in its role in normal and patho­logical brain processes, with emphasis on Parkinson's disease (PD) and epileptic disorders.
Stéphane Charpier   +4 more
openaire   +2 more sources

GABAergic interneurons in human subthalamic nucleus

Movement Disorders, 2005
AbstractThe subthalamic nucleus (STN) is considered a homogeneous structure composed essentially of projection neurons that exert a profound glutamate‐mediated excitatory influence upon the main output structures of the basal ganglia. It is currently the most efficient target for deep brain stimulations designed to alleviate symptoms of Parkinson's ...
Julie-Christine Lévesque, André Parent
openaire   +3 more sources

The Subthalamic Nucleus

2016
The glutamatergic subthalamic nucleus (STN) is a key node in the cortico-basal ganglia-thalamo-cortical circuit. As a component of the hyperdirect and indirect pathways, the STN is important for constraining movement, thought, and emotion through synaptic excitation of GABAergic basal ganglia output neurons.
openaire   +2 more sources

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