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GABAergic interneurons in human subthalamic nucleus
Movement Disorders, 2005AbstractThe subthalamic nucleus (STN) is considered a homogeneous structure composed essentially of projection neurons that exert a profound glutamate‐mediated excitatory influence upon the main output structures of the basal ganglia. It is currently the most efficient target for deep brain stimulations designed to alleviate symptoms of Parkinson's ...
Julie-Christine, Lévesque +1 more
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Somatotopic Localization in Rhesus Subthalamic Nucleus
Archives of Neurology, 1962In 1947, Mettler and Whittier 1 were able to produce abnormal bodily movements in monkeys by placing lesions in the subthalamic nucleus. These movements, occurring for the most part in the limbs, closely resembled those seen in ballism (flinging movements) or, more broadly, chorea ("dancing" movements).
F A, METTLER, G M, STERN
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Neurophysiological Refinement of Subthalamic Nucleus Targeting
Neurosurgery, 2002ABSTRACT OBJECTIVE Advances in image-guided stereotactic surgery, microelectrode recording techniques, and stimulation technology have been the driving forces behind a resurgence in the use of functional neurosurgery for the treatment of movement disorders.
Djordje, Sterio +6 more
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Histogenesis of the subthalamic nucleus
Neuroscience, 1987Literature presents divergent hypotheses on the histogenesis of the subthalamic nucleus. The basal plate of the mesencephalon, the dorsal hypothalamus (or the longitudinal subthalamic zone) and an area closely related to the mammillary nucleus have all been proposed as the site of origin of the neurons of the subthalamic nucleus.
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The microcircuitry of primate subthalamic nucleus
Parkinsonism & Related Disorders, 2007Single-cell labeling experiments in cynomolgus monkeys have revealed that the subthalamic nucleus (STN) harbors several subtypes of projection neurons, each endowed with a highly patterned set of axon collaterals. This organizational feature allows single STN neurons to act directly upon the two major output structures of the basal ganglia--the ...
Martin, Parent, André, Parent
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GABAergic control of the subthalamic nucleus
2007The glutamatergic subthalamic nucleus (STN) is a key component of the basal ganglia, a group of subcortical brain nuclei important for voluntary movement and the site of dysfunction in Parkinson's disease. The rate and pattern of STN activity is precisely regulated by the reciprocally connected GABAergic external globus pallidus (GP(e)) and ...
Mark D, Bevan +2 more
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History and future challenges of the subthalamic nucleus as surgical target: Review article
Movement Disorders, 2018For many years the subthalamic nucleus had a poor reputation among neurosurgeons as a result of the acute movement disorders that develop after its lesion or manipulation through different surgical procedures.
J. Guridi +5 more
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High frequency subthalamic nucleus stimulation
2020The remarkable clinical effectiveness of deep brain stimulation (DBS) for the treatment of an expanding range of neurological dysfunction will have profound implications. DBS has given emphasis to a whole new approach utilizing the electrical nature of brain function.
Erwin B Montgomery +2 more
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Subthalamic nucleus and gait disturbance
Neurology, 2004Although subthalamic nucleus (STN) deep brain stimulation (DBS) is now an established treatment for patients with advanced Parkinson disease (PD),1 its mechanism of action remains poorly understood. Because the clinical effect of DBS is similar to lesioning, DBS was initially thought to inactivate the target site but there is emerging evidence that it ...
Robert Chen, Roger Lemon
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2016
The glutamatergic subthalamic nucleus (STN) is a key node in the cortico-basal ganglia-thalamo-cortical circuit. As a component of the hyperdirect and indirect pathways, the STN is important for constraining movement, thought, and emotion through synaptic excitation of GABAergic basal ganglia output neurons.
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The glutamatergic subthalamic nucleus (STN) is a key node in the cortico-basal ganglia-thalamo-cortical circuit. As a component of the hyperdirect and indirect pathways, the STN is important for constraining movement, thought, and emotion through synaptic excitation of GABAergic basal ganglia output neurons.
openaire +1 more source