Results 201 to 210 of about 43,824 (266)

Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1‐linked episodic ataxia in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville, Ryan F. Yoshimura, Hanh A. Nguyen, Ruiming Zhao, Derk J. Hogenkamp, Steve A. N. Goldstein, Geoffrey W. Abbott   +6 more
wiley   +1 more source

The Effect of Medical Therapies for Subthreshold Abdominal Aortic Aneurysm Growth and Mortality: A Network Meta-Analysis of Randomized Controlled Trials. [PDF]

Interdiscip Cardiovasc Thorac Surg
Lu PYJ, Seth I, Fung CHC, Varcoe R, Rozen W, Joseph K.   +5 more
europepmc   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Comparison of the efficacy of subthreshold micropulse laser versus intravitreal anti-VEGF therapy for chronic central serous chorioretinopathy. [PDF]

Front Med (Lausanne)
Li J, Zhu T, Zhu Y, Wang Y, Wu H, Chen Z.   +5 more
europepmc   +1 more source

Comparative efficacy of non-pharmacological therapies in adolescents with subthreshold depression: a systematic review and network meta-analysis. [PDF]

Front Psychiatry
Ji Q, Wang Z, Wang X, Zhou L, Lou Z, Su M, Gao X, Jiang S, Qiu H, Luo Z.   +9 more
europepmc   +1 more source

Late-onset major depression and subthreshold depressive symptoms as early clinical correlates of brain small vessel disease. [PDF]

Int J Neuropsychopharmacol
Mitkani CA, Tegos TJ, Kimiskidis VK, Koukou S, Fountoulakis KN.   +4 more
europepmc   +1 more source

Nano-Power OTA-Based Low-Pass Filter for Ultra-Low-Energy Biomedical Signal Processing. [PDF]

Sensors (Basel)
Kulej T, Kumngern M, Khateb F.
europepmc   +1 more source

Childhood adversities and post-traumatic stress: predictive pathways through acute stress disorder. [PDF]

BJPsych Open
Al Barathie J, Chamoun M, Osman R, Karam EG.   +3 more
europepmc   +1 more source

Design and performance analysis of a vertically stacked gate-all-around nanosheet FET with embedded nanocavity for biosensing applications. [PDF]

Sci Rep
Prasanna RL, Karumuri SR, Sreenivasulu VB, Kondaveeti GS.   +3 more
europepmc   +1 more source