Results 211 to 220 of about 100,071 (296)

Adult‐onset Coats disease: A systematic review and meta‐analysis of imaging biomarkers and targeted therapies

open access: yesActa Ophthalmologica, EarlyView.
Abstract Coats disease diagnosed in adulthood is a rare idiopathic retinal telangiectatic vasculopathy that may differ in phenotype from childhood‐diagnosed cases. This systematic review synthesizes current evidence to characterize its clinical spectrum, imaging features, treatment outcomes and underlying mechanisms, with a focus on immunovascular ...
Catarina Francisco   +2 more
wiley   +1 more source

The impact of sleep duration, sleep debt and insomnia symptoms on infection risk: a longitudinal cohort study with 1-year follow-up. [PDF]

open access: yesFam Pract
Bjorvatn B   +7 more
europepmc   +1 more source

Serial dependence in time perception requires consistent motor responses, not shared memory alone

open access: yesBritish Journal of Psychology, EarlyView.
Abstract Serial dependence—the bias from recent experience on present response—has been attributed to shared memory representations, yet previous studies yielded contradictory findings about whether consistent motor responses are required. To address this debate in time perception, we tested whether serial dependence emerges when tasks share identical ...
Jiao Wu   +2 more
wiley   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Drugst.One DREAM—Drug repurposing through expert annotation and modification

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Complex diseases often lack an actionable understanding of their underlying causal biological mechanisms, which leads to treating symptoms rather than causes. Network and systems medicine define disease mechanisms through disease‐associated genes, their encoded proteins and their protein–protein interactions (PPIs), thus forming ...
Lisa M. Spindler   +8 more
wiley   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

open access: yesThe FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti   +3 more
wiley   +1 more source

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