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Aging Cell, 2007 SummaryAging is a complex, multifactorial process. One of the features of normal aging of the brain is a decline in cognitive functions and much experimental attention has been devoted to understanding this process. Evidence accumulated in the last decade indicates that such functional changes are not due to gross morphological alterations, but to ...
Emil C Toescu
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Subtle Memory Decline over 12 Months in Mild Cognitive Impairment
Dementia and Geriatric Cognitive Disorders, 2004<i>Objective:</i> Screening of normal older persons for progressive memory decline is a worthwhile strategy in the pursuit of the earliest possible stages of pre-clinical Alzheimer’s disease (AD) or mild cognitive impairment (MCI). Reliable tests are needed to both detect MCI and measure the natural history of decline over months rather ...
P, Maruff +5 more
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Multimodal biomarker characterization of amnestic objective subtle cognitive decline
Abstract Background Alzheimer’s disease (AD) diagnostic guidelines acknowledge transitional decline prior to clinical onset, yet the absence of practical recommendations for defining this stage presents a major challenge for early detection and risk stratification.David López-Martos +18 more
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European Journal of Nuclear Medicine and Molecular Imaging
This study evaluated the differences in amyloid-β (Aβ), tau deposition, and longitudinal tau deposition between subjective cognitive decline (SCD) and objective subtle cognitive difficulties (Obj-SCD).Participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort (n = 234) and the Huashan cohort (n = 267) included individuals with Obj ...
Xiaoxie Mao +11 more
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This study evaluated the differences in amyloid-β (Aβ), tau deposition, and longitudinal tau deposition between subjective cognitive decline (SCD) and objective subtle cognitive difficulties (Obj-SCD).Participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort (n = 234) and the Huashan cohort (n = 267) included individuals with Obj ...
Xiaoxie Mao +11 more
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Journal of Clinical and Experimental Neuropsychology
Introduction: The deterioration of autobiographical memory (AM) and autonoetic consciousness is central in Alzheimer’s Disease (AD). Here, we investigated the presence of AM alterations in a potential preclinical stage of AD known as Subjective Cognitive Decline (SCD), characterized by a self-reported worsening in cognitive functioning without an ...
Matilde Conti +10 more
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Introduction: The deterioration of autobiographical memory (AM) and autonoetic consciousness is central in Alzheimer’s Disease (AD). Here, we investigated the presence of AM alterations in a potential preclinical stage of AD known as Subjective Cognitive Decline (SCD), characterized by a self-reported worsening in cognitive functioning without an ...
Matilde Conti +10 more
openaire +1 more source
Subtle cognitive decline in a patient with depression and anxiety
Current Psychiatry, 2023openaire +1 more source