Results 151 to 160 of about 560,921 (309)

Mapping Alzheimer’s disease heterogeneity through exploratory unsupervised learning

Frontiers in Aging Neuroscience
IntroductionAlzheimer’s disease (AD) is becoming one of the most pressing health challenges of the century, affecting circa 55 million people worldwide and expected to triple this number by 2050.
Catarina Xavier, Ana Paula Correia, Joana Lopes, Joana Fernandes, Inês Laranjinha, Nádia Pinto, Nádia Pinto, Nádia Pinto   +7 more
doaj   +1 more source

Distributed Subtyping [PDF]

One of the most frequent operations in object-oriented programs is the "instanceof" test, also called the "subtyping" test or the "type inclusion" test. This test determines if a given object is an instance of some type.
Guerraoui, Rachid, Barreto, Joao, Baehni, Sébastien   +2 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Subtyping Patterns for Active Objects

, 2000
Subtyping relations for object-oriented formalisms describe relationships between super- and subclasses which satisfy the substitutability requirement imposed on types and their subtypes.
Heike Wehrheim
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The value of targeted CXCR4 18F-AlF-NOTA-pentixafor PET/CT for subtyping primary aldosteronism

Frontiers in Endocrinology
ObjectiveThe study aimed to investigate the diagnostic value of 18F-AlF-NOTA-Pentixafor PET/CT in subtyping primary aldosteronism (PA).MethodsThis study enrolled 88 patients with PA or nonfunctional adenoma (NFA) for 18F-Pentixafor PET/CT scan. Of these,
Yushi Peng, Fangansheng Chen, Rui Yao, Junping Lan, Yinuo Fu, Kaifeng Ye, Zhiqiang Wang, Qianxiu Zhao, Xiaowei Ji, Kang Xia, Guoqing Zhu, Kewen Zheng, Xuemei Gu, Kun Tang, Kun Tang, Kun Tang   +15 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Subtyping Functional+Nonempty Record Types

, 1999
\begin{abstract} \emph{Solving systems of subtype constraints} (or \emph{subtype inequalities}) is in the core of efficient \emph{type reconstruction} in modern object-oriented languages with subtyping and inheritance, two problems known ...
Sergei Vorobyov, Vorobyov, S.
core   +1 more source