En España está muy de moda solicitar subvenciones, ya sea al estado, la autonomía, el municipio o el barrio. Hay casos en los que dichas subvenciones no tienen sentido, como en el de las ONG´s. Una ONG subvencionada implica contradicción en los términos.
José Antonio Martínez Pons
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One-Pot Morita-Baylis-Hillman/Allylic Substitution in Deep Eutectic Solvents: Access to γ-Hydroxy Derivatives via Sequential CC and CX (X = P, N, S, B, Si) Bond Formation. [PDF]
Sustainable one‐pot synthesis of functionalized γ‐hydroxy derivatives in deep eutectic solvents. A green, sequential CC/CX bond‐forming strategy enables diverse γ‐hydroxy derivatives via Morita–Baylis–Hillman and nucleophilic functionalization in ChCl/Gly deep eutectic solvent.
Ramos-Martín M +3 more
europepmc +2 more sources
Incorporation of Cryptic Plasmid Energetics Improves Genome-Scale Metabolic Predictions in Probiotic E. coli Nissle 1917. [PDF]
This study presents the expansion of genome‐scale models of Escherichia coli Nissle 1917 to account for the metabolic cost of its cryptic plasmids. Through systematic comparison with previous reconstructions and validation against fluxomics datasets, the models improved accuracy in predicting growth and overall metabolic fluxes.
Corbín-Agustí P +6 more
europepmc +2 more sources
Modular, Tricomponent, and Concurrent One-Pot Synthesis of Libraries of γ-Keto Sulfones and γ-Keto Phosphine Oxides using Brønsted Acidic Eutectic Mixtures. [PDF]
This study presents a sustainable, metal‐free, one‐pot synthesis of γ‐keto sulfones and phosphine oxides using a ChCl/p‐TSA·H2O eutectic mixture. The method enables regioselective CC and CX bond formation under mild conditions, aligning with Green Chemistry Principles.
Ramos-Martín M +2 more
europepmc +2 more sources
Pubertal development and hypothalamic-pituitary-gonadal axis are altered in male mice lacking Mecp2. [PDF]
Abstract Mutations in the MECP2 gene, encoding the epigenetic reader Methyl‐CpG binding protein 2, are the main cause of Rett syndrome, a rare neurodevelopmental disorder. Besides severe symptoms such as profound intellectual disability, loss of speech and motor skills, and epilepsy, loss of function of MECP2 has been associated with pubertal ...
Martín-Sánchez A +6 more
europepmc +2 more sources
Solvent-Controlled Chemoselectivity in Brønsted Acidic Deep Eutectic Mixtures: A Metal-Free One-Pot Cascade Meyer-Schuster/C-P Bond Formation. [PDF]
Brønsted Acidic Deep Eutectic Solvents (BADESs, acting as solvent, promoter, and chemoselectivity controller) based on choline chloride (ChCl) and p‐toluenesulfonic acid (p‐TSA·H2O) enable one‐pot cascade, metal‐free Meyer‐Schuster/C‐P (and C‐Cl) tandem process. Variations in the ChCl:p‐TSA·H2O ratios switches chemoselectivity, affording α‐hydroxy or α‐
Morís-Menéndez G +4 more
europepmc +2 more sources
Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition. [PDF]
Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Canto A +6 more
europepmc +2 more sources
La OMC y las subvenciones pesqueras [PDF]
La pesca excesiva es una situación que afecta a todos los países del mundo y las subvenciones permitidas pueden para este rubro acrecentar esta problemática.
Patricia Gualdoni, Elizabeth Errazti
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Lección 24. Actividad de promoción y fomento
SUMARIO: 1. INTRODUCCIÓN.—2. MARCO NORMATIVO: 2.1. Tipología de la actividad promocional y de fomento; 2.2. Riesgos de la actividad promocional y de fomento y fundamentos de su regulación.—3.
Fernando Pastor Merchante
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En la UE, la crisis económica generada por la pandemia ha requerido la puesta en marcha de un esfuerzo financiero extraordinario: los fondos europeos NextGenerationEU.
María Amparo Salvador Armendáriz
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