Results 11 to 20 of about 681 (162)

One-Pot Morita-Baylis-Hillman/Allylic Substitution in Deep Eutectic Solvents: Access to γ-Hydroxy Derivatives via Sequential CC and CX (X = P, N, S, B, Si) Bond Formation. [PDF]

ChemSusChem
Sustainable one‐pot synthesis of functionalized γ‐hydroxy derivatives in deep eutectic solvents. A green, sequential CC/CX bond‐forming strategy enables diverse γ‐hydroxy derivatives via Morita–Baylis–Hillman and nucleophilic functionalization in ChCl/Gly deep eutectic solvent.
Ramos-Martín M, Del Río I, García-Álvarez J, Presa Soto A.   +3 more
europepmc   +2 more sources

Incorporation of Cryptic Plasmid Energetics Improves Genome-Scale Metabolic Predictions in Probiotic E. coli Nissle 1917. [PDF]

Microb Biotechnol
This study presents the expansion of genome‐scale models of Escherichia coli Nissle 1917 to account for the metabolic cost of its cryptic plasmids. Through systematic comparison with previous reconstructions and validation against fluxomics datasets, the models improved accuracy in predicting growth and overall metabolic fluxes.
Corbín-Agustí P, Arévalo-Lalanne A, Álvarez P, Enrique M, Ramón D, Peretó J, Tortajada M.   +6 more
europepmc   +2 more sources

Modular, Tricomponent, and Concurrent One-Pot Synthesis of Libraries of γ-Keto Sulfones and γ-Keto Phosphine Oxides using Brønsted Acidic Eutectic Mixtures. [PDF]

ChemSusChem
This study presents a sustainable, metal‐free, one‐pot synthesis of γ‐keto sulfones and phosphine oxides using a ChCl/p‐TSA·H2O eutectic mixture. The method enables regioselective CC and CX bond formation under mild conditions, aligning with Green Chemistry Principles.
Ramos-Martín M, García-Álvarez J, Presa Soto A.   +2 more
europepmc   +2 more sources

Pubertal development and hypothalamic-pituitary-gonadal axis are altered in male mice lacking Mecp2. [PDF]

J Neuroendocrinol
Abstract Mutations in the MECP2 gene, encoding the epigenetic reader Methyl‐CpG binding protein 2, are the main cause of Rett syndrome, a rare neurodevelopmental disorder. Besides severe symptoms such as profound intellectual disability, loss of speech and motor skills, and epilepsy, loss of function of MECP2 has been associated with pubertal ...
Martín-Sánchez A, Jiménez-Díaz D, Esteve-Pérez R, Vasile-Tudorache A, Read JE, Howard SR, Agustín-Pavón C.   +6 more
europepmc   +2 more sources

Solvent-Controlled Chemoselectivity in Brønsted Acidic Deep Eutectic Mixtures: A Metal-Free One-Pot Cascade Meyer-Schuster/C-P Bond Formation. [PDF]

ChemSusChem
Brønsted Acidic Deep Eutectic Solvents (BADESs, acting as solvent, promoter, and chemoselectivity controller) based on choline chloride (ChCl) and p‐toluenesulfonic acid (p‐TSA·H2O) enable one‐pot cascade, metal‐free Meyer‐Schuster/C‐P (and C‐Cl) tandem process. Variations in the ChCl:p‐TSA·H2O ratios switches chemoselectivity, affording α‐hydroxy or α‐
Morís-Menéndez G, Ríos-Lombardía N, Ramos-Martín M, Presa Soto A, García-Álvarez J.   +4 more
europepmc   +2 more sources

Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition. [PDF]

J Neuroendocrinol
Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Canto A, Valero-Ochando J, López-Pedrajas R, Olivar T, Hernández-Rabaza V, Almansa I, Miranda M.   +6 more
europepmc   +2 more sources

SUBVENCIONES E IMPUESTO SOBRE EL VALOR AÑADIDO: ANÁLISIS DE LA JURISPRUDENCIA EUROPEA [PDF]

Crónica Tributaria, 2011
La consideración tributaria de las subvenciones en relación con el impuesto sobre el valor añadido es distinta en función de que se vinculen o no al precio del servicio prestado o del bien entregado por la entidad subvencionada.
Sergio Alonso de León
doaj   +2 more sources

La animación española en 2012

Con A de Animación, 2013
Tras un período de cuatro años de intensa crisiseconómica, en 2012 comienza a resquebrajarse partede la fortaleza que la animación española había mostradohasta el momento, viendo desaparecer con granrapidez algunos de las empresas y eventos insigniadel ...
Samuel Viñolo Locuviche
doaj   +1 more source

Presente y futuro de las ayudas a la industria cinematográfica española

Fotocinema: Revista Científica de Cine y Fotografía, 2017
El descenso continuado de los principales indicadores de la industria cinematográfica española revela la crisis de un sector incapaz de hacer frente a un conjunto de problemas agravados por la subida del IVA cultural al 21%, junto con una rebaja ...
Olga Heredero Díaz, Francisco Reyes Sánchez   +1 more
doaj   +1 more source

El nuevo delito de fraude a subvenciones

Derecho Penal y Criminología, 2013
En la década de los setenta se evidenció en Colombia que algunos ciudadanos obtenían indebidamente recursos del Estado simulando exportaciones o desviando el fin para el que se les habían concedido créditos oficialmente regulados.
Hernando A. Hernández Quintero
doaj   +2 more sources