Results 11 to 20 of about 84,318 (209)

One-Pot Morita-Baylis-Hillman/Allylic Substitution in Deep Eutectic Solvents: Access to γ-Hydroxy Derivatives via Sequential CC and CX (X = P, N, S, B, Si) Bond Formation. [PDF]

ChemSusChem
Sustainable one‐pot synthesis of functionalized γ‐hydroxy derivatives in deep eutectic solvents. A green, sequential CC/CX bond‐forming strategy enables diverse γ‐hydroxy derivatives via Morita–Baylis–Hillman and nucleophilic functionalization in ChCl/Gly deep eutectic solvent.
Ramos-Martín M, Del Río I, García-Álvarez J, Presa Soto A.   +3 more
europepmc   +2 more sources

Incorporation of Cryptic Plasmid Energetics Improves Genome-Scale Metabolic Predictions in Probiotic E. coli Nissle 1917. [PDF]

Microb Biotechnol
This study presents the expansion of genome‐scale models of Escherichia coli Nissle 1917 to account for the metabolic cost of its cryptic plasmids. Through systematic comparison with previous reconstructions and validation against fluxomics datasets, the models improved accuracy in predicting growth and overall metabolic fluxes.
Corbín-Agustí P, Arévalo-Lalanne A, Álvarez P, Enrique M, Ramón D, Peretó J, Tortajada M.   +6 more
europepmc   +2 more sources

Modular, Tricomponent, and Concurrent One-Pot Synthesis of Libraries of γ-Keto Sulfones and γ-Keto Phosphine Oxides using Brønsted Acidic Eutectic Mixtures. [PDF]

ChemSusChem
This study presents a sustainable, metal‐free, one‐pot synthesis of γ‐keto sulfones and phosphine oxides using a ChCl/p‐TSA·H2O eutectic mixture. The method enables regioselective CC and CX bond formation under mild conditions, aligning with Green Chemistry Principles.
Ramos-Martín M, García-Álvarez J, Presa Soto A.   +2 more
europepmc   +2 more sources

Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition. [PDF]

J Neuroendocrinol
Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Canto A, Valero-Ochando J, López-Pedrajas R, Olivar T, Hernández-Rabaza V, Almansa I, Miranda M.   +6 more
europepmc   +2 more sources

Staging Parkinson's disease according to the MNCD classification correlates with caregiver burden

Brain and Behavior, Volume 13, Issue 12, December 2023., 2023
Recently, it has been reported that staging Parkinson's disease (PD) with a novel simple classification called MNCD, based on 4 axes (Motor; Non‐motor; Cognition; Dependency) and 5 stages, correlated with disease severity and patients' quality of life.
Diego Santos‐García, Teresa de Deus Fonticoba, Carlos Cores Bartolomé, María J. Feal Painceiras, Iago García Díaz, María Cristina Íñiguez Alvarado, Jose Manuel Paz, Silvia Jesús, Marina Cosgaya, Juan García Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernández Vara, Iria Cabo, Lydia López Manzanares, Isabel González Aramburu, Maria A. Ávila Rivera, Víctor Gómez Mayordomo, Víctor Nogueira, Julio Dotor García‐Soto, Carmen Borrué, Berta Solano Vila, María Álvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Zebenzui Mendoza, Juan C. Martínez Castrillo, Pilar Sánchez Alonso, Maria G. Alonso Losada, Nuria López Ariztegui, Itziar Gastón, Jaime Kulisevsky, Manuel Seijo, Caridad Valero, Ruben Alonso Redondo, Maria Teresa Buongiorno, Carlos Ordás, Manuel Menéndez‐González, Darrian McAfee, Pablo Martinez‐Martin, Pablo Mir, COPPADIS Study Group   +42 more
wiley   +1 more source

Expanded and Independent Spanish Validation of the MDS‐Non Motor Rating Scale

Movement Disorders Clinical Practice, Volume 10, Issue 4, Page 586-595, April 2023., 2023
Abstract Background The Movement Disorder Society‐sponsored Non‐motor Rating Scale (MDS‐NMS) assess the severity and disability caused by non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective This article encapsulates the formal process for completing this program and the data on the first officially approved non‐English version of the MDS ...
Esther Cubo, Sheng Luo, Pablo Martínez‐Martín, Glenn T. Stebbins, Jeffrey Lin, Dongrak Choi, Alvaro García‐Bustillo, Pablo Mir, Diego Santos‐Garcia, Marcos Serrano‐Dueñas, Mayela Rodriguez‐Violante, Carlos Singer, and the Spanish MDS‐NMS Validation Study Group, Carmen Borrue Fernández, Marina Mata Alvarez‐Santullano, Iria Cabo, Inés Legarda Ramírez, María Fuensanta Valero García, Bárbara Vives Pastor, Anna Planas, Nuria Caballol Pons, Asunción Ávila, Nuria López Ariztegui, Mª. Isabel Morales Casado, Mar Sierra Peña, María Victoria Sánchez Peláez, Sonia Escalante Arroyo, Lidia Binela Lara Lezama, María Álvarez Sauco, Gustavo Fernández Pajarín, Fernando Alonso Frech, Víctor Gómez Mayordomo, Álvaro Sánchez Ferro, David Seoane Fernández, Carmen Gasca Salas, Elena, Natera Villalba, Dra Samaniego‐Toro, Jorge Hernández‐Vara, Nelida Garretto, Tomoko Arakaki, Henry Moore, Ingrid Estrada‐Bellmann, Ivonne Pedroso, Oscar Bernal   +44 more
wiley   +1 more source

Crónica legislativa de Aragón. Segundo semestre de 2022.

Revista de Llengua i Dret - Journal of Language and Law, 2023
El texto recoge las novedades normativas que afectan a los usos, a los derechos lingüísticos y al régimen jurídico de las lenguas en Aragón aprobadas durante el segundo semestre de 2022, sin que exista ningún tipo de jurisprudencia.
Fernando Javier García Fernández
doaj   +1 more source

El agujero negro de los premios literarios municipales

Revista de Estudios de la Administración Local y Autonómica, 2021
Se analizan los premios literarios concedidos por las entidades locales, en particular los que conllevan la publicación de las obras premiadas. Pese a que las Administraciones Públicas deben someterse a un procedimiento riguroso que garantice la ...
Miguel José Izu Belloso
doaj   +1 more source

SUBVENCIONES E IMPUESTO SOBRE EL VALOR AÑADIDO: ANÁLISIS DE LA JURISPRUDENCIA EUROPEA [PDF]

Crónica Tributaria, 2011
La consideración tributaria de las subvenciones en relación con el impuesto sobre el valor añadido es distinta en función de que se vinculen o no al precio del servicio prestado o del bien entregado por la entidad subvencionada.
Sergio Alonso de León
doaj   +2 more sources

Las subvenciones de la administración local en materia de deporte en Cataluña

Apunts: Educación Física y Deportes, 2015
Los poderes públicos catalanes, y muy en concreto los entes locales, desarrollan acciones de fomento del deporte mediante subvenciones para responder a las necesidades sociales y económicas de personas y entidades.
Jesús Auré i Calvet
doaj   +1 more source