Results 51 to 60 of about 3,501,679 (303)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Sherry Jiang (Student Success Coach Showcase Series)

, 2022
Introductory video from PAVE Student Success Coach, Sherry ...
Sherry Jiang
core   +1 more source

Cardiotoxicity screening of long‐term, breast cancer survivors—The CAROLE (Cardiac‐Related Oncologic Late Effects) Study

Cancer Medicine, 2021
Background Long‐term breast cancer survivors are at risk for cardiotoxicity after treatment, but there is insufficient evidence to provide long‐term (~10 years) cardiovascular disease (CVD) screening recommendations.
Lindsay L. Puckett, Shahryar G. Saba, Sonia Henry, Stacey Rosen, Elise Rooney, Samaria L. Filosa, Philip Gilbo, Karalyn Pappas, Alison Laxer, Katherine Eacobacci, Amitha N. Kapyur, Justin Robeny, Samantha Musial, Anisha Chaudhry, Rahul Chaudhry, Martin L. Lesser, Adam Riegel, Sariah Ramoutarpersaud, Navid Rahmani, Amar Shah, Vivian Papas, Toluwani Dawodu, Jessica Charlton, Jonathan P. S. Knisely, Lucille Lee   +24 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Academic Success

, 2021
Academic Success is an open textbook designed to help students on their university journey. It is divided into four parts, each reflecting different aspects of a student’s tertiary experience. Part A: Successful Beginnings addresses what it is like to be
Sahay, Akshay, Derrington, Kate, McGregor, Rowena, Hargreaves, Wendy, Peters, Emma, Schultz, Susanne, Conway, Sam, Irvine, Sarah, Rose, Yvonne, Tweedale, Robyn, Bartlett, Cristy, Howarth, Debi, Pickstone, Leigh, Retallick, Bianca, Frederiks, Anita, Devi, Aruna, Clark, Linda, Gunton, Lyndelle, Jeffers, Marjorie, Lovric, Kristen, Sachdeva, Karanpal Singh, Cawthray, Tyler, Thangavelu, Anbarasu   +22 more
core   +1 more source

Helen Aquilina (Student Success Coach Showcase Series)

, 2022
Introductory video from PAVE Student Success Coach, Helen ...
Helen Aquilina
core   +1 more source

Exploring the Role of Radiosurgery for Atypical Meningiomas: Addressing Suboptimal Local Control in High-Risk Patients

Advances in Radiation Oncology
Purpose: Despite recent advancements in the treatment of atypical meningioma, control rates in high-risk patients continue to be suboptimal. Stereotactic radiosurgery (SRS) offers the ability to achieve improved local control (LC) with a low toxicity ...
Sanjeev Sreenivasan, MD, MCh, Salem Najjar, BA, Daniel Ma, MD, Sabrina L. Begley, BS, Yen-Ruh Wuu, MD, Zaker Rana, MD, Emile Gogineni, DO, Michael Schulder, MD, Anuj Goenka, MD   +8 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

ELITES- Pathways to Success

, 2012
European cities are becoming increasingly diverse. The aim of the ELITES, Pathways to Success projects is to explore today’s new (upcoming) elite in Europe’s large cities: successful entrepreneurs, people working in high-skilled jobs and in leadership ...
Lelie, F, Crul, MRJ, Schneider, J
core   +1 more source