Results 121 to 130 of about 909,011 (310)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Final Report of the Commission on Presidential Disability and the Twenty-Fifth Amendment [PDF]
, 1988 This Report examines the Twenty-Fifth Amendment to identify potential difficulties in presidential succession and makes ...
Bayh, Birch E., Jr. +4 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
, 1995 Consider the problem of multinomial estimation. You are given an alphabet of k distinct symbols and are told that the i-th symbol occurred exactly n_i times in the past.
Ristad, Eric Sven
core +4 more sources
Systematic lithostratigraphy of the Neogene succession exposed in central parts of Hawke’s Bay Basin, eastern North Island, New Zealand [PDF]
, 2007 This report presents a systematic lithostratigraphy for the Neogene (Miocene–Recent) sedimentary succession in central parts of Hawke’s Bay Basin in eastern North Island, New Zealand.
Bland, Kyle J. +2 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Журнал Белорусского государственного университета: География, геология, 2017 The article tracks the changes in the bird population during secondary succession of cleared spruce forest in SouthWestern Belarus. The field work was performed in the years 1992–2012 applying the conventional bird count methods.
Irina V. Abramova
doaj
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source