Results 151 to 160 of about 909,011 (310)

Structural change in the presence of network externalities: a co-evolutionary model of technological successions [PDF]

open access: yes
The paper examines the conditions under which technological successions can occur in the presence of network externalities. A two-stage, multi-agent simulation model is presented in which product designs co-evolve with consumer preferences. It provides a
Birchenhall,Chris, Windrum,Paul
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Catalan-like numbers and succession rules

open access: yes, 2005
The ECO method and the theory of Catalan-like numbers introduced by Aigner seems two completely unrelated combinatorial settings. In this work we try to establish a bridge between them, aiming at starting a (hopefully) fruitful study on their ...
Ferrari, Luca, Pinzani, Renzo
core  

Multidimensional Recovery of Young Secondary Forests in Human-Modified Tropical Landscapes. [PDF]

open access: yesGlob Chang Biol
Matsuo T   +11 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Forest Succession Shapes Soil microbial Communities through Region-specific Edaphic Filters in Tropical and Subtropical Forests. [PDF]

open access: yesMicrob Ecol
Muhammad W   +11 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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