Results 181 to 190 of about 949,782 (341)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Beyond a viral succession timeline: a phase-transition framework and re-analysis highlight hidden instability in the proposed "phage clock". [PDF]

Appl Environ Microbiol
La N, Rattanapitoon NK, Thanchonnang C, Rattanapitoon SK.   +3 more
europepmc   +1 more source

Digital legacy: reflections on regulation and challenges in the succession of digital assets

, 2023
Jonas Martins da Costa, Carlos Roberto Ferreira Brandão, Danilo Henrique Nunes, Celso Barberato   +3 more
openalex   +2 more sources

Can the cosmological constant undergo abrupt changes?

, 2005
The existence of a simple spherically symmetric and static solution of the Einstein equations in the presence of a cosmological constant vanishing outside a definite value of the radial distance is investigated.
Cabo, Alejandro, Garcia-Chung, Alejandro, Rosabal, Alejandro   +2 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Community assembly following disturbance in batch anaerobic digesters displays highly reproducible secondary succession and a shifting stochastic-deterministic balance. [PDF]

Front Microbiomes
Guerrero-Toledo FM, Espinosa-Solares T, Hernández-Eugenio G, Huber DH.   +3 more
europepmc   +1 more source

The Succession in the Augustan Principate

, 2007
Deogsu Kim
openalex   +1 more source

Modelling of Vegetation Dynamics from Satellite Time Series to Determine Proglacial Primary Succession in the Course of Global Warming—A Case Study in the Upper Martell Valley (Eastern Italian Alps)

, 2021
Bettina Knoflach, Katharina Ramskogler, Lauren Talluto, Florentin Hofmeister, Florian Haas, Tobias Heckmann, Madlene Pfeiffer, Livia Piermattei, Camillo Ressl, Michael Wimmer, Clemens Geitner, Brigitta Erschbamer, Johann Stötter   +12 more
openalex   +1 more source

Succession Planning [PDF]

Journal of Oncology Practice, 2008
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source