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Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source
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Success and Succession

Journal of the American Psychoanalytic Association, 2004
The etymology of the word success and its relationship to succession is elucidated. Linkage is made to the consequences of unconscious “legitimate” and “illicit” fulfillments in life. This is explored in the writings of Freud and others. Emphasis is placed on guilt, a major factor blocking the attainment of success.
Irwin H, Marill, Everett R, Siegel
openaire   +2 more sources

Three Perspectives on a Successful Succession

Frontiers of Health Services Management, 2020
SUMMARY Leadership succession does not need to be extremely difficult. However, it does require time, a carefully planned process, well-defined roles, and the intent of all parties to achieve a successful transition—along with the trust to make these various aspects come together. In a CEO succession, the work does not begin at
Tim, Lancaster   +2 more
openaire   +2 more sources

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