Results 91 to 100 of about 667 (143)

Dimercaptosuccinic acid (succimer; DMSA) in inorganic lead poisoning

Clinical Toxicology, 2009
This article reviews data on the efficacy of succimer (dimercaptosuccinic acid, DMSA) in the treatment of human inorganic lead poisoning, the adverse effects associated with its use, and summarizes current understanding of the pharmacokinetic and pharmacodynamic aspects.Medline, Toxline, and Embase were searched and 912 papers were identified and ...
Allister Vale
exaly   +3 more sources

The effects of succimer chelation therapy on auditory function in rhesus monkeys

Neurotoxicology and Teratology, 2001
Sixty-six female rhesus monkeys were randomly assigned to three lead exposure conditions (none, from birth to 1 year, and from birth to 2 years) by two chelation treatment (succimer and no succimer) conditions. Blood lead levels were maintained at 35-40 microg/dl beginning shortly after birth and continuing for 1 or 2 years postnatally.
Melissa L Luck, Robert E Lasky, Nellie K Laughlin   +2 more
exaly   +3 more sources

Toxicokinetics of Mercury Elimination by Succimer in Twin Toddlers

Pediatric Drugs, 2005
We describe the toxicokinetics of mercury in two twin toddlers poisoned by an East Indian remedy for teething. Succimer (dimercaprosuccinic acid, DMSA) decreased the plasma elimination half-life of mercury by 3-fold in the patient with high exposure; a more modest effect was observed in the other twin.
Ibrahim, Fayez, Michelle, Paiva, Margaret, Thompson, Zulfukarali, Verjee, Gideon, Koren   +4 more
openaire   +2 more sources

Succimer

Reactions Weekly, 2023
  +5 more sources

Succimer and the Reduction of Tissue Lead in Juvenile Monkeys

Toxicology and Applied Pharmacology, 2000
The extent to which succimer (2,3-dimercaptosuccinic acid, DMSA) chelation reduces target organ lead (Pb) levels, including the skeleton, relative to the cessation of Pb exposure is a primary consideration in evaluating its efficacy for reducing toxicity in children.
D R, Smith, D, Woolard, M L, Luck, N K, Laughlin   +3 more
openaire   +2 more sources

Succimer for treatment of lead toxicosis in two cats

Journal of the American Veterinary Medical Association, 2001
Two cats from a single household were examined because of neurologic abnormalities suggestive of central vestibular disease. The owner had been renovating her 150-year-old house for the preceding 3 months, and renovations included chipping and sanding of old paint from windowsills and stair railings. Lead toxicosis was diagnosed on the basis of history
T E, Knight, M, Kent, J E, Junk
openaire   +2 more sources

Rash and pyrexia after succimer (dimercaptosuccinic acid; DMSA)

Clinical Toxicology, 2017
Sir,We have reviewed previously [1] the adverse effects of succimer (dimercaptosuccinic acid; DMSA) and described a patient who developed a mucocutaneous reaction 2 days after the commencement of a...
Anneka, Varma, Sally M, Bradberry, J Allister, Vale   +2 more
openaire   +2 more sources

The Treatment of Lead Poisoning from Gunshot Wounds with Succimer (DMSA)

Journal of Toxicology: Clinical Toxicology, 1994
Lead poisoning is an unusual complication of gunshot wounds that occurs when retained lead bullet fragments are in contact with body fluids capable of solubilizing lead. The epidemic of violence by gunfire may result in increasing numbers of lead poisoning cases from this exposure.
W J, Meggs, F, Gerr, M H, Aly, T, Kierena, D L, Roberts, R, Shih, H C, Kim, R, Hoffman   +7 more
openaire   +2 more sources

Succimer treatment and calcium supplementation reduce tissue lead in suckling rats

Journal of Applied Toxicology, 2004
AbstractThe effect of combined treatment with meso‐2,3‐dimercaptosuccinic acid (DMSA) and calcium supplementation in reducing lead absorption and enhancing lead elimination was evaluated in suckling rats under two experimental conditions: during ongoing oral lead exposure (lead acetate, 2 mg Pb kg−1 day−1, total dose 16 mg Pb kg−1) or after lead ...
Varnai, Veda Marija, Matek Sarić, Marijana, Jureša, Dijana, Piasek, Martina, Blanuša, Maja, Kostial-Šimonović, Krista   +5 more
openaire   +3 more sources

The Effect of Chelation Therapy with Succimer on Neuropsychological Development in Children Exposed to Lead

New England Journal of Medicine, 2001
Thousands of children, especially poor children living in deteriorated urban housing, are exposed to enough lead to produce cognitive impairment. It is not known whether treatment to reduce blood lead levels prevents or reduces such impairment.We enrolled 780 children with blood lead levels of 20 to 44 microg per deciliter (1.0 to 2.1 micromol per ...
W J, Rogan, K N, Dietrich, J H, Ware, D W, Dockery, M, Salganik, J, Radcliffe, R L, Jones, N B, Ragan, J J, Chisolm, G G, Rhoads   +9 more
openaire   +2 more sources