Results 91 to 100 of about 215,979 (293)

Biological Functions of Succinate (a Review of Foreign Experimental Studies)

Антибиотики и Химиотерапия, 2020
The published data on the modern concept of the biological role of succinate, an intermediate of the citric acid cycle are analysed in the review. Special interest to succinate is determined by investigations on the mitochondrial functions at different ...
V. V. Valeev, A. L. Kovalenko, E. V. Talikova, V. A. Zaplutanov, T. Yu. Delvig-Kamenskaya   +4 more
doaj  

Lithium salts of Krebs cycle substrates as potential normothymic antioxidant agents

Journal of Pharmacy and Bioallied Sciences, 2018
Objective: Aim of the present work was to study the antioxidant properties of lithium salts of Krebs cycle substrates and their influence on immune cells. Lithium is a well-known and widely used mood stabilizer.
Evgenii Plotnikov, Elena Korotkova, Olesya Voronova   +2 more
doaj   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Succinate Regulates Exercise‐Induced Muscle Remodelling by Boosting Satellite Cell Differentiation Through Succinate Receptor 1

Journal of Cachexia, Sarcopenia and Muscle
Background Skeletal muscle remodelling can cause clinically important changes in muscle phenotypes. Satellite cells (SCs) myogenic potential underlies the maintenance of muscle plasticity. Accumulating evidence shows the importance of succinate in muscle
Yifan Shi, Da Zhou, Haoyang Wang, Longchang Huang, Xuejin Gao, Gulisudumu Maitiabula, Li Zhang, Xinying Wang   +7 more
doaj   +1 more source

Actinobacillus succinogenes in Bioelectrochemical Systems: Influence of Electric Potentials and Carbon Fabric Electrodes on Fermentation Performance

Microorganisms
The fermentation of Actinobacillus succinogenes in bioelectrochemical systems offers a promising approach to enhance biotechnological succinate production by shifting the redox balance towards succinate and simultaneously enabling CO2 utilization.
Julian Tix, Jan-Niklas Hengsbach, Joshua Bode, Fernando Pedraza, Julia Willer, Sei Jin Park, Kenneth F. Reardon, Roland Ulber, Nils Tippkötter   +8 more
doaj   +1 more source

Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors.

Biochimica et biophysica acta. Reviews on cancer, 2020
Macrophages are innate phagocytic leukocytes that are highly present in solid tumors, where they are referred to as tumor-associated macrophages (TAMs).
M. Kes, J. van den Bossche, A. Griffioen, E. Huijbers   +3 more
semanticscholar   +1 more source

Combining Electrochemical Reduction with Biosynthesis for Directed Conversion of CO2 into a Library of C3 Chemicals

Advanced Science, EarlyView.
In the H‐type electrolytic cell, carbon dioxide is reduced to acetic acid via electro‐microbial catalysis. The simply processed acetic acid is further converted through biological fermentation into high‐value‐added products, including acrylic acid, L‐lactic acid, and β‐alanine.
Kaixing Xiao, Shanquan Liang, Xujun Zhao, Zhiyao Peng, Ruoshi Luo, Jikai Zong, Ling Zhou, Yude Su, Dan Wang   +8 more
wiley   +1 more source

Succinate in innate immunity: linking metabolic reprogramming to immune modulation

Frontiers in Immunology
Succinate is an essential metabolite in the tricarboxylic acid (TCA) cycle. In mitochondria, succinate holds a unique position connecting the TCA cycle and the electron transport chain (ETC), thereby providing a shortcut path for adenosine triphosphate ...
Reham Atallah, Juergen Gindlhuber, Akos Heinemann   +2 more
doaj   +1 more source

Conformation‐Modulated Lignin for Durable and High‐Output Cellulosic Triboelectric Materials Toward Self‐Powered Sensing

Advanced Science, EarlyView.
Conformation‐engineered alkali lignin with flexible aliphatic side chains is integrated into cellulose to suppress tribo‐induced fiber fibrillation and interfacial wear. Dynamic chain adaptability enhances frictional energy dissipation and dielectric polarization, enabling durable, high‐output triboelectric sensing with excellent recyclability and ...
Lujie Wang, Jian Du, Yilin Wang, Tianshuang Bao, Chao Li, Yehan Tao, Jinwen Hu, Chenglong Fu, Dong Lv, Weiwei Zhao, Zhanhui Yuan, Haisong Wang   +11 more
wiley   +1 more source

Grape Seed Polyphenols Enhance Antioxidant Activity and Prolong the Lifespan of Caenorhabditis elegans Through SKN‐1/Nrf2 Pathway

AgriFood: Journal of Agricultural Products for Food, EarlyView.
GSP extends C. elegans lifespan, enhances stress resistance and reproduction, boosts antioxidant defenses (↑SOD/CAT/GSH‐Px, ↓ROS), remodels glycolysis/TCA/one‐carbon metabolism dose‐dependently, and activates SKN‐1/Nrf2 and H3K4 methylation—linking redox control to epigenetic modulation.
Boya Ouyang, Quanyong Wu, Fei Liu, Jingyimei Liang, Wanning Ma, Yuxuan Zhao, Hui Cao, Jianbo Xiao   +7 more
wiley   +1 more source