Results 251 to 260 of about 215,979 (293)

Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion.

Kidney International, 2023
Ischemia-reperfusion (IR) injury, a leading cause of acute kidney injury (AKI), is still without effective therapies. Succinate accumulation during ischemia followed by its oxidation during reperfusion leads to excessive reactive oxygen species (ROS) and
C. J. Oh, Min-Ji Kim, Ji-Min Lee, Dong Hun Kim, Il-Young Kim, Sanghee Park, Yeongmin Kim, Kyung-Bok Lee, Sang-Hee Lee, C. Lim, Myeongjin Kim, Jung-Yi Lee, Haushabhau S Pagire, Suvarna H Pagire, M. Bae, Dipanjan Chanda, T. Thoudam, A. Khang, R. A. Harris, J. Ahn, Jae-Han Jeon, In-Kyu Lee   +21 more
semanticscholar   +1 more source

Comprehensive Overview of Carboxamide Derivatives as Succinate Dehydrogenase Inhibitors.

Journal of Agricultural and Food Chemistry, 2022
Up to now, a total of 24 succinate dehydrogenase inhibitors (SDHIs) fungicides have been commercialized, and SDHIs fungicides were also one of the most active fungicides developed in recent years. Carboxamide derivatives represented an important class of
B. Luo, Yuli Ning
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Gut microbiota-derived succinate aggravates acute lung injury after intestinal ischaemia/reperfusion in mice

European Respiratory Journal, 2022
Introduction Acute lung injury (ALI) is a major cause of morbidity and mortality after intestinal ischaemia/reperfusion (I/R). The gut microbiota and its metabolic byproducts act as important modulators of the gut–lung axis.
Yiheng Wang, Zhengzheng Yan, Sihan Luo, Jingjuan Hu, Mei Wu, Jin Zhao, Wei-Feng Liu, Cai Li, Ke-xuan Liu   +8 more
semanticscholar   +1 more source

2-Aminopyridinium–succinate–succinic acid (2/1/1)

Acta Crystallographica Section C Crystal Structure Communications, 2002
In the title compound, 2C(5)H(7)N(2)(+).C(4)H(4)O(4)(2-).C(4)H(6)O(4), cyclic eight-membered hydrogen-bonded rings exist involving 2-aminopyridinium and succinate ions. The succinic acid and succinate moieties lie on inversion centres. Succinic acid molecules and succinate ions are linked into zigzag chains by O-H.O hydrogen bonds, with O.O distances ...
Buyukungor, O, Odabaşoğlu, Mustafa
openaire   +2 more sources

Desvenlafaxine succinate monohydrate

Acta Crystallographica Section C Crystal Structure Communications, 2008
The title compound {systematic name: [2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl)ethyl]dimethylammonium 3-carboxypropanoate monohydrate}, C(16)H(26)NO(2)(+) x C(4)H(5)O(4)(-) x H(2)O, is a succinate salt of O-desmethylvenlafaxine (desvenlafaxine). The present structure is one of four reported polymorphs of this salt, which is a new antidepressant drug.
Nalivela, Venu, Bukkapattanam R, Sreekanth, Thaimattam, Ram, Surya, Devarakonda   +3 more
openaire   +2 more sources

Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection.

European Heart Journal, 2021
AIMS Aortic aneurysm and dissection (AAD) are high-risk cardiovascular diseases with no effective cure. Macrophages play an important role in the development of AAD.
Hongtu Cui, Yanghui Chen, Ke Li, Rui Zhan, Mingming Zhao, Yangkai Xu, Zhiyong Lin, Yi Fu, Qi-hua He, P. Tang, Ienglam Lei, Jifeng Zhang, Chenze Li, Yang Sun, Xinhua Zhang, T. Horng, Hong S. Lu, Y. E. Chen, A. Daugherty, Daowen Wang, Lemin Zheng   +20 more
semanticscholar   +1 more source

Host succinate is an activation signal for Salmonella virulence during intracellular infection

Science, 2021
Salmonella profits from immunometabolism Extensive metabolic rewiring occurs in various immune cells during the course of infection. Whether these changes can be exploited by intracellular pathogens remains an open question. Rosenberg et al.
G. Rosenberg, D. Yehezkel, Dotan Hoffman, C. Mattioli, Moran Fremder, Hadar Ben-Arosh, Leia Vainman, Noa Nissani, Shelly Hen-Avivi, Shirley Brenner, M. Itkin, S. Malitsky, Ehud Ohana, N. B. Ben-Moshe, R. Avraham   +14 more
semanticscholar   +1 more source

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.

Cancer Cell, 2005
Several mitochondrial proteins are tumor suppressors. These include succinate dehydrogenase (SDH) and fumarate hydratase, both enzymes of the tricarboxylic acid (TCA) cycle. However, to date, the mechanisms by which defects in the TCA cycle contribute to
M. Selak, S. Armour, Elaine D. MacKenzie, Houda Boulahbel, D. G. Watson, K. Mansfield, Yi Pan, M. Simon, C. Thompson, E. Gottlieb   +9 more
semanticscholar   +1 more source

Regulation of succinate dehydrogenase and role of succinate in cancer.

Seminars in Cell and Developmental Biology, 2020
Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme with the unique property to participate in both the citric acid cycle and the electron transport chain.
E. Dalla Pozza, I. Dando, Raffaella Pacchiana, E. Liboi, M. Scupoli, Massimo Donadelli, M. Palmieri   +6 more
semanticscholar   +1 more source