Results 111 to 120 of about 382,582 (334)

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis

Exploration, EarlyView.
NaCr promotes KCr to impede the inflammatory progression of ulcerative colitis. KCr induces mitophagy by activating the PINK1/PARKIN pathway to restrict NLRP3 inflammasome activation, thereby decreasing the production and release of various inflammatory cytokines, such as IL‐1β and TNF‐α. KCr induces mitophagy and inhibits NLRP3 inflammasome activation
Tongtong Liu, Binyan Lin, Ying Zhang, Jiayu Su, Xiaochao Hu, Xuan Wang, E‐Hu Liu, Shijia Liu   +7 more
wiley   +1 more source

Metabolomic Profiling of Probiotic Lactobacillus acidophilus Strain LA01 on Bovine Bone Powder Fermentation

Food Chemistry International, EarlyView.
Probiotic Lactobacillus acidophilus strain LA01 was applied to bone powder fermentation. The adsorbable calcium, small peptides, and compounds with lipid‐lowering and antioxidant properties were greatly enriched. This study provided insights into the metabolism of probiotic fermentation and laid the scientific basis for development of value‐added ...
Ruijie Zhang, Yangfan Hu, Wenqing Wang, Bo Yu   +3 more
wiley   +1 more source

Gut Microbiota‐Bile Acid Metabolism Axis Drive Anti‐Diabetic Effects of Polygonatum cyrtonema Polysaccharide on Glycolipid Metabolism and Intestinal Inflammation

Food Frontiers, EarlyView.
PCP‐80% could lessen the pathophysiology of T2DM in terms of controlling blood glucose/lipid levels and enhancing intestinal barrier function, via modulating the intricate web of intestinal microbiota/BAs/BAs signaling pathways. Red vertical arrows denote increases (HPCP‐80% vs. MC), blue vertical arrows indicate decreases (HPCP‐80% vs.
Xiaole Zhao, Bing Zheng, Tianxiang Ao, Jianhua Xie, Yi Chen, Hesham El‐Seedi, Hairong Huang, Baoting Liu, Qiang Yu   +8 more
wiley   +1 more source

Sulfated Polysaccharides in the Hallmarks of Metabolic Syndrome: Functions and Mechanisms

Food Frontiers, EarlyView.
The SPs sources are very diverse, including various fishes, sea cucumbers, seaweeds, etc. These SPs are able to improve the glucose and lipid metabolism disorders, hormonal dysregulation, oxidative stress, inflammatory response, complications, and gut homeostasis of MetS by regulating biochemical indicators related to MetS. ABSTRACT Metabolic syndrome (
Fuqiang Zhao, Chuan Li, Xin Zhang, Kexue Zhu, Chao Zhao, Deming Gong, Lulu Zhu, Yongcheng Li, Jun Cao, Shaoping Nie   +9 more
wiley   +1 more source

S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase.

Cancer Research, 2016
S-nitrosoglutathione reductase (GSNOR) represents the best-documented denitrosylase implicated in regulating the levels of proteins posttranslationally modified by nitric oxide on cysteine residues by S-nitrosylation.
S. Rizza, C. Montagna, S. Cardaci, Emiliano Maiani, G. Di Giacomo, Virginia Sanchez-Quiles, B. Blagoev, A. Rasola, D. De Zio, J. Stamler, F. Cecconi, G. Filomeni   +11 more
semanticscholar   +1 more source

The distribution of succinate dehydrogenase and malate dehydrogenase among components of tobacco-leaf extracts [PDF]

, 1963
WS Pierpoint
openalex   +1 more source

Predictive Factors of Malignancy in Cervical Paragangliomas: A Retrospective Study

Head &Neck, EarlyView.
ABSTRACT Background Early predictive factors of metastatic cervical paragangliomas (cPG) are lacking. Methods This multicenter retrospective study included patients with at least one cPG. Metastatic cPG were defined by the histological presence of lymph node metastases or distant metastases.
Garance Haw, Maxime Fieux, Anthime Flaus, Hélène Lasolle, Juliette Abeillon, Myriam Decaussin‐Petrucci, Dylan Pavie, Benjamin Verillaud, Philippe Herman, Patrick Feugier, Fatima Ameur, Pierre Philouze, Françoise Borson‐Chazot, Philippe Ceruse   +13 more
wiley   +1 more source

Prediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) against Rickettsia felis using integrated computational approaches

Frontiers in Veterinary Science
Rickettsia felis, responsible for flea-borne spotted fever, is a rising zoonotic pathogen posing an increasing global threat due to its expanding geographical distribution.
Sudais Rahman, Hsien Liu, Mohibuallah Shah, Mashal M. Almutairi, Iram Liaqat, Tetsuya Tanaka, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Abdulaziz Alouffi, Abid Ali   +11 more
doaj   +1 more source

Activation of liver succinate dehydrogenase in rats exposed to hypobaric conditions [PDF]

, 1969
H. N. Aithal, T. Ramasarma
openalex   +1 more source