Results 281 to 290 of about 382,582 (334)

KAT2A‐H3K79succ‐Mediated SH2B3 Upregulation Promotes TNBC Metastasis Through Diminishing the Ubiquitin‐Dependent Degradation of Vimentin

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Lysine acetyltransferase 2A (KAT2A) is a critical catalytic component within transcriptional regulatory complexes and plays a significant role in triple‐negative breast cancer (TNBC). To investigate its underlying mechanism, this study demonstrates that KAT2A catalyzes succinylation at the H3K79 site to promote SH2B3 transcription and enhance its ...
Xiaohui Shi, Ran Hao, Zhan Yang, Xiaoran Wang, Yiwei Lu, Xiaohan Wang, Huanqi Ji, Shen Ma, Xuehua Liu, Jie Hu, Yixin Qi   +10 more
wiley   +1 more source

Racial differences in kidney cancer histology and outcome: A nationwide study from the UroCCR Cohort

Cancer, Volume 131, Issue 20, 15 October 2025.
ABSTRACT Introduction Racial differences in renal cell carcinoma (RCC) have been well described in U.S. cohorts, particularly for common histologic subtypes. However, such differences remain underexplored in European populations, especially for rare RCC subtypes and within universal health care settings.
Xiaofan Lu, Jean‐Christophe Bernhard, Gaëlle Margue, François Audenet, Nicolas Doumerc, Pierre Merlin, Morgan Roupret, Thibaut Waeckel, Cécile Champy, Louis Surlemont, Jonathan Olivier, Nicolas Branger, Bastien Parier, Victor Gaillard, Franck Bruyere, Alexis Fontenil, Constance Michel, Louis Vignot, Jean‐Luc Descotes, Guillaume Loison, Julien Guillotreau, Fayek Taha, Frédéric Panthier, Stéphane De Vergie, Idir Ouzaid, Romain Boissier, Jean‐Jacques Patard, Pierre Gimel, Igor Duquesne, Khalil Chalhoub, Pierre Bigot, Gabriel G. Malouf   +31 more
wiley   +1 more source

Dimethyl malonate preserves renal and mitochondrial functions following ischemia-reperfusion via inhibition of succinate dehydrogenase. [PDF]

Redox Biol
Carlström M, Rannier Ribeiro Antonino Carvalho L, Guimaraes D, Boeder A, Schiffer TA.   +4 more
europepmc   +1 more source

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou, Xi Xiong, Jialong Hou, Qi Duan, Yi Zheng, Tao Jiang, Jiani Huang, Haijun He, Jiaxue Xu, Keke Chen, Wenwen Wang, Jinlai Cai, Jingjing Qian, Huijun Chen, Weihong Song, XinShi Wang, Chenglong Xie   +16 more
wiley   +1 more source

MCT1‐mediated Lactate Shuttle to Mitochondria Governs Macrophage Polarization and Modulates Glucose Homeostasis by Affecting β Cells

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen, Yijun Lin, Xinyu Zhu, Shixuan Zhuo, Zixuan Li, Cheng Guo, Xiaoyi Ye, Jinzhu Chen, Shuying Wang, Yan Chen   +9 more
wiley   +1 more source

Robotic Resection in Succinate Dehydrogenase Subunit B (SDHB)-Mutated Hereditary Paraganglioma: A Case Report of Two Patients and A Literature Review. [PDF]

Cureus
Baron E, Wu CC, Gupta K, Wernberg JA, Sheehan MT, Sharma R.   +5 more
europepmc   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, Volume 12, Issue 40, October 27, 2025.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source