Results 291 to 300 of about 382,582 (334)

Regulation of succinate dehydrogenase and role of succinate in cancer

Seminars in Cell & Developmental Biology, 2020
Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme with the unique property to participate in both the citric acid cycle and the electron transport chain. However, in recent years, several studies have highlighted the role of the SDH substrate, i.e.
Dalla Pozza, Elisa, Dando, Ilaria, Pacchiana, Raffaella, Liboi, Elio, Scupoli, Maria Teresa, Donadelli, Massimo, Palmieri, Marta   +6 more
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Comprehensive Overview of Carboxamide Derivatives as Succinate Dehydrogenase Inhibitors.

Journal of Agricultural and Food Chemistry, 2022
Up to now, a total of 24 succinate dehydrogenase inhibitors (SDHIs) fungicides have been commercialized, and SDHIs fungicides were also one of the most active fungicides developed in recent years. Carboxamide derivatives represented an important class of
B. Luo, Yuli Ning
semanticscholar   +1 more source

Discovery of a Fungicide Candidate Targeting Succinate Dehydrogenase via Computational Substitution Optimization.

Journal of Agricultural and Food Chemistry, 2021
Succinate dehydrogenase (SDH, EC 1.3.5.1) has proven to be an important fungicidal target, and the inhibition of SDH is useful in the treatment of plant pathogens. The discovery of a novel active SDH inhibitor is of high value.
Hua Li, Yu-Xia Wang, Xiao-Lei Zhu, Guangfu Yang   +3 more
semanticscholar   +1 more source

Design, Synthesis and Evaluation of Antifungal Activity of Novel Pyrazole-thiazole Carboxamides as Succinate Dehydrogenase Inhibitors.

Journal of Agricultural and Food Chemistry, 2020
Succinate dehydrogenase (SDH) is regarded as a promising target for fungicide discovery. To continue our ongoing studies on the discovery of novel SDH inhibitors as fungicides, novel pyrazole-thiazole carboxamides were designed, synthesized, and ...
Bin Yu, Shuang Zhou, Lixin Cao, Zesheng Hao, Dongyan Yang, Xiaofeng Guo, Nailou Zhang, V. Bakulev, Zhijin Fan   +8 more
semanticscholar   +1 more source

Succinate dehydrogenase II. The effect of phospholipases on particulate and soluble succinate dehydrogenase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1969
Abstract 1. 1.|The activity of beef-heart succinate dehyrogenase (succinate:(acceptor) oxidoreductase, EC 1.3.99.1) in particulate preparations is not affected by phospholipase A (phosphatide acyl-hydrolase, EC 3.1.1.4) but is inhibited by the action of phospholipase C (phosphatidylcholine cholinephosphohydrolase EC 3.1.4.3), and of phospholipase
Maria Adelaide Giovenco, Maria Adelaide Giovenco, Paola Caiafa, Paola Caiafa, M.G. Giordano, M.G. Giordano, Paolo Cerletti, Paolo Cerletti   +7 more
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Interactions of succinate dehydrogenase with cyanide

Biochimica et Biophysica Acta (BBA) - Enzymology, 1973
Succinate dehydrogenase (succinate:(acceptor) oxidoreductase, EC 1.3.99.1) solubilized by KCN, differs from other soluble preparations of this enzyme for the following properties. 1. 1. It has 16–20 nmoles of tightly bound cyanide per mg protein. 2. 2. It contains 3.6–4.1 nmoles of peptide-bound flavin, 24–32 natoms of iron and 16–17 nmoles of
Zanetti G., Galante Y. M., AROSIO, Paolo, Cerletti P.   +3 more
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[47] Mammalian succinate dehydrogenase

1978
Publisher Summary This chapter discusses the four aspects of mammalian succinate dehydrogenase: (1) a critical comparison of assay methods, (2) activation–deactivation of the enzyme, (3) the active site of the enzyme, and (4) the comparison of the properties of various purified preparations including recent improvements of procedures for isolating ...
Thomas P. Singer, Edna B. Kearney, Brian A. C. Ackrell   +2 more
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Succinate dehydrogenase deficiency in human

Cellular and Molecular Life Sciences, 2005
Mitochondrial succinate dehydrogenase (SDH) consists merely of four nuclearly encoded subunits. It participates in the electron transfer in the respiratory chain and in succinate catabolism in the Krebs cycle. Mutations in the four genes, SDHA, B, C and D, have been reported, resulting in strikingly diverse clinical presentations.
Brière, J.-J., Favier, J., El Ghouzzi, V, Djouadi, F., Bénit, P., Gimenez, A-P, Rustin, P., Ghouzzi, V. El., Gimenez, A. -P.   +8 more
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Studies in succinate dehydrogenase histochemistry [PDF]

Histochemie, 1973
The activity of succinate tetrazolium reductase was investigated in liver and kidney from the rat and mouse. The results obtained were related to the cellular level of succinate dehydrogenase (SDH) as well as to the level of CoQ.
Helge Andersen, P. E. Høyer
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Activation of succinate dehydrogenase by bicarbonate

Biochemical and Biophysical Research Communications, 1978
Abstract Succinate dehydrogenase (SD) of mitochondria from rat liver or kidney is to a large extent in the active form as isolated, whereas SD activity of heart and skeletal muscle mitochondria can be activated as much as ten-fold over the basal activity when isolated.
E.Jack Davis, Julian Swierczynski
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