Results 91 to 100 of about 1,800 (193)
The role of appoptosin in regulating oxidative stress and mitochondrial morphology [PDF]
, 2015 氧化压力是指细胞或体内氧自由基的含量超出抗氧化物及抗氧化酶类清除能力时对细胞或机体造成的氧化胁迫。氧化压力参与了包括炎症、衰老、心血管疾病、癌症、糖尿病、艾滋病、神经退行性疾病等多种疾病的发病过程。氧化压力通过多个下游信号通路对细胞造成胁迫，如JNK、Foxo等，但其中的具体参与蛋白仍有待于深入阐明。Appoptosin也被称为SLC25A38，是一种定位于线粒体内膜的转运蛋白，负责转入甘氨酸并转出D-氨基乙酰丙酸，进而调节血红素（heme）的合成 ...
张翠林
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Journal of Clinical Laboratory Analysis, Volume 38, Issue 7, April 2024.We carried out a systematic review of the use of dried biofluids in kidney disease. The majority of studies focused on drug quantification following transplant. However, dried biofluids were comparable with venous samples opening up the possibility to expand to biomarker discovery.
Megan K. Lamond +3 more
wiley +1 more source
Tyrosinemia type I: clinical and biochemical analysis of patients in Mexico
Annals of Hepatology, 2014 Introduction. Hepatorenal tyrosinemia (HT1) is a treatable, inherited, metabolic disease characterized by progressive liver failure with pronounced coagulopathy.
Cynthia Fernández-Lainez +5 more
doaj +1 more source
Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency [PDF]
, 2017 Previous work has demonstrated that the function of extrahepatic cytochrome P450 CYP1A1 is dependent on the availability of heme. CYP1A1 is involved in the activation of polyaromatic hydrocarbons.
Hoffmann, Francine +3 more
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Recommendations for the management of tyrosinaemia type 1
Orphanet Journal of Rare Diseases, 2013 The management of tyrosinaemia type 1 (HT1, fumarylacetoacetase deficiency) has been revolutionised by the introduction of nitisinone but dietary treatment remains essential and the management is not easy.
de Laet Corinne +8 more
doaj +1 more source
LABRAD : Vol 41, Issue 3 - December 2015 [PDF]
, 2015 Overview on Approach to Inherited Bleeding Disorders Diagnostic Approach to Haemoglobinopathies Transient Abnormal Myelopoiesis Urinary Tract Infections (UTI) in Children Role of Histopathology in the Diagnosis of Paediatric Renal Tumours Role of ...
Aga Khan University Hospital, Karachi
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Metabolomics Based Profiling of Dexamethasone Side Effects in Rats
Frontiers in Pharmacology, 2018 Dexamethasone (Dex) is a synthetic glucocorticoid that has anti-inflammatory and immunosuppressant effects and is used in several conditions such as asthma and severe allergy.
Abeer K. Malkawi +12 more
doaj +1 more source
Newborn screening for inborn errors of metabolism and endocrinopathies: an update [PDF]
, 2018 Newborn screening for inborn errors of metabolism and endocrinopathies has expanded during the last two decades, mainly owing to the introduction of new technologies such as tandem mass spectrometry and DNA analysis.
Fingerhut, Ralph, Olgemöller, Bernhard
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Investigation of newborn blood metabolomics in varying intrauterine growth conditions
Jornal de PediatriaObjectives: This study aimed to investigate changes in the blood metabolic profiles of newborns with varying intrauterine growth conditions. Specifically, we analyzed the levels of amino acids, carnitine, and succinylacetone among full-term newborns ...
Shengwen Wang +7 more
doaj +1 more source