Results 151 to 160 of about 1,764 (178)
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Immunosuppression by succinylacetone. II. Prevention of graft-vs-host disease.
The Journal of Immunology, 1987Abstract Succinylacetone is a seven-carbon organic ketoacid that we have previously shown to inhibit tumor allograft rejection as well as the primary antibody response to sheep erythrocytes in rats. Because it appeared to be such a potent immunosuppressive agent in our initial studies, we evaluated succinylacetone for its ability to ...
R A, Hess, D P, Tschudy, R M, Blaese
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Plasma succinylacetone is persistently raised after liver transplantation in tyrosinaemia type 1
Journal of Inherited Metabolic Disease, 2012AbstractBackgroundTyrosinaemia type 1 (HT1) is a rare disorder leading to accumulation of toxic metabolites such as succinylacetone (SA) and a high risk of hepatocellular carcinoma. Children with HT1 traditionally required liver transplantation (OLT) and while the need for this has been reduced by the introduction of nitisinone some still require OLT ...
David C, Bartlett +5 more
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Clinica Chimica Acta, 1981
Succinylacetone was excreted in the urine from four patients, with hereditary tyrosinemia i.e., two patients with the severe infantile type with fatal outcome and two patients with less severe juvenile form. In the urine from two patients with neonatal transient tyrosinemia and from normal individuals succinylacetone was not detectable.
E, Christensen +6 more
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Succinylacetone was excreted in the urine from four patients, with hereditary tyrosinemia i.e., two patients with the severe infantile type with fatal outcome and two patients with less severe juvenile form. In the urine from two patients with neonatal transient tyrosinemia and from normal individuals succinylacetone was not detectable.
E, Christensen +6 more
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Immunopharmacology, 1992
Succinylacetone (SA) proved to be a potent inhibitor of in vitro lymphoproliferative responses. This compound (3.0 mM) reduced the incorporation of 3HTdr by > 90% in mononuclear cell cultures stimulated with PHA, anti-CD3, IL-2 or phorbol dibutyrate-Ca2+ ionomycin.
A, Winkelstein +5 more
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Succinylacetone (SA) proved to be a potent inhibitor of in vitro lymphoproliferative responses. This compound (3.0 mM) reduced the incorporation of 3HTdr by > 90% in mononuclear cell cultures stimulated with PHA, anti-CD3, IL-2 or phorbol dibutyrate-Ca2+ ionomycin.
A, Winkelstein +5 more
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Immunosuppressive activity of succinylacetone.
The Journal of laboratory and clinical medicine, 1982SA, an inhibitor of ALA dehydrase, the second enzyme of the heme biosynthetic pathway, has been shown to exert immunosuppressive activity in several systems. When the Walker 256 tumor was grown subcutaneously in outbred Sprague-Dawley rats, SA prevented rejection of the tumor by the host.
D P, Tschudy +3 more
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Lack of Hemodynamic Effects After Extended Heme Synthesis Inhibition by Succinylacetone in Rats
The Journal of Pharmacology and Experimental Therapeutics, 2010Hypertyrosinemia (HT) is a life-threatening condition caused in large part by the buildup of tyrosine metabolites and their derivatives. One such metabolite is succinylacetone (SA), a potent irreversible inhibitor of heme biosynthesis. Heme is a key component of numerous enzymes involved in arterial blood pressure (BP) regulation, including nitric ...
Stephane L, Bourque +3 more
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Renal heme metabolism in hereditary tyrosinemia: use of succinylacetone in rat renal tubules
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1991Succinylacetone (SA), a metabolic end-product found in urine from individuals with hereditary tyrosinemia and associated renal Fanconi syndrome and a known inhibitor of hepatic 5-aminolevulinic acid dehydratase (ALAD), has been used to study heme metabolism in isolated rat renal tubules.
P A, Wyss +5 more
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Evaluation of succinylacetone and nitisinone measurement: analytical performance requirements
2022SSIEM22-2210Novel diagnostic/laboratory methods including omicsEvaluation of succinylacetone and nitisinone measurement: analytical performance requirementsList of authors:Ridvan Murat Öktem*⠀⠀1, Asli Inci⠀⠀1, Gürsel Biberoglu⠀⠀1, Ilyas Okur⠀⠀1, Fatih Süheyl Ezgü⠀⠀1, Leyla Tümer⠀⠀11 Gazi University, Ankara* = presenting authorBackground: While blood ...
İnci, Aslı +5 more
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Evaluation of factors influencing accuracy in the analysis of succinylacetone in dried blood spots
Clinica Chimica Acta, 2012Dried blood spots offer specific advantages over conventional blood collection methods, but with certain limitations. This article aims to evaluate factors which affect succinylacetone test in dried blood spots.Whole blood with defined hematocrit and blood volume spiked with succinylacetone was spotted on filter paper, and analyzed by liquid ...
Minzhi, Peng, Li, Liu, Lijun, Peng
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Journal of Chromatography B, 2005
The presence of succinylacetone in urine or blood or amniotic fluid is pathognomonic of an inherited metabolic disorder, named tyrosinemia type I. We developed a capillary electrophoretic method for the fast analysis of succinylacetone in urine samples.
M Serif, Cansever, F Bedia, Erim
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The presence of succinylacetone in urine or blood or amniotic fluid is pathognomonic of an inherited metabolic disorder, named tyrosinemia type I. We developed a capillary electrophoretic method for the fast analysis of succinylacetone in urine samples.
M Serif, Cansever, F Bedia, Erim
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