Results 151 to 160 of about 1,800 (193)
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Determination of Urinary Succinylacetone by Capillary Gas Chromatography
Journal of Chromatographic Science, 1984The average analytical recovery of succinylacetone added to urine and separated by capillary gas chromatography was 69% for solvent extraction and 72% for anion exchange separation. Treating succinylacetone with hydroxylamine hydrochloride at a pH of less than 5 caused formation of a derivative separated by capillary gas chromatography into two isomers:
M, Tuchman +5 more
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Synthesis and immunosuppressive activity of novel succinylacetone analogues
Archives of Pharmacal Research, 2003This study describes the synthesis of novel enol esters (3) and triketones (4) as analogues of succinylacetone (SA) (Ed- this abbreviation is introduced here based on your use of it in the body of the paper) and the evaluation on the mouse allogeneic mixed lymphocyte reaction (MLR) and the murine model of antigen-induced paw edema formation for ...
Taek Hyeon, Kim +3 more
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Effects of succinylacetone on growth and respiration of L1210 leukemia cells
Cancer Letters, 19854,6-Dioxoheptanoic acid (succinylacetone, SA), a potent inhibitor of heme biosynthesis, suppressed growth and decreased respiration of L1210 leukemia cells in vitro. Growth of cells incubated in the presence of 2--4 mM SA for the first 2 days declined, and after 3 days virtually ceased.
E C, Weinbach, P S, Ebert
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Treatment of experimental autoimmune uveitis in the rat with systemic succinylacetone
Clinical Immunology and Immunopathology, 1988The effects of succinylacetone (SA) on the development of S-antigen-induced experimental autoimmune uveitis (EAU) in the rat were studied. SA totally suppressed EAU at Day 14 when animals were treated with a constant infusion of 1.80 mg/hr by an osmotic minipump. Three intervals of treatment with this dose rate were used (Day 0-7, Day 7-14, or Day 0-14)
S A, Skolik +4 more
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Effects of succinylacetone on amino acid uptake in the rat kidney
Biochemical Medicine and Metabolic Biology, 1987Infants with hereditary tyrosinemia also have a renal Fanconi syndrome and excrete succinylacetone (SA). We have studied the effects of SA on rat renal tubular amino acid transport in vivo and in vitro using isolated renal tubules. Injection of SA produces increased clearance of several amino acids in the intact animal.
P D, Spencer, K S, Roth
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Clinica Chimica Acta, 1981
Succinylacetone was excreted in the urine from four patients, with hereditary tyrosinemia i.e., two patients with the severe infantile type with fatal outcome and two patients with less severe juvenile form. In the urine from two patients with neonatal transient tyrosinemia and from normal individuals succinylacetone was not detectable.
E, Christensen +6 more
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Succinylacetone was excreted in the urine from four patients, with hereditary tyrosinemia i.e., two patients with the severe infantile type with fatal outcome and two patients with less severe juvenile form. In the urine from two patients with neonatal transient tyrosinemia and from normal individuals succinylacetone was not detectable.
E, Christensen +6 more
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Immunopharmacology, 1992
Succinylacetone (SA) proved to be a potent inhibitor of in vitro lymphoproliferative responses. This compound (3.0 mM) reduced the incorporation of 3HTdr by > 90% in mononuclear cell cultures stimulated with PHA, anti-CD3, IL-2 or phorbol dibutyrate-Ca2+ ionomycin.
A, Winkelstein +5 more
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Succinylacetone (SA) proved to be a potent inhibitor of in vitro lymphoproliferative responses. This compound (3.0 mM) reduced the incorporation of 3HTdr by > 90% in mononuclear cell cultures stimulated with PHA, anti-CD3, IL-2 or phorbol dibutyrate-Ca2+ ionomycin.
A, Winkelstein +5 more
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Immunosuppressive activity of succinylacetone.
The Journal of laboratory and clinical medicine, 1982SA, an inhibitor of ALA dehydrase, the second enzyme of the heme biosynthetic pathway, has been shown to exert immunosuppressive activity in several systems. When the Walker 256 tumor was grown subcutaneously in outbred Sprague-Dawley rats, SA prevented rejection of the tumor by the host.
D P, Tschudy +3 more
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A CASE OF TYROSINAEMIA TYPE I WITH NORMAL LEVEL OF SUCCINYLACETONE IN THE AMNIOTIC FLUID
Prenatal Diagnosis, 1996Prenatal diagnosis of tyrosinaemia type I can be achieved in cultured amniotic cells and in chorionic villus material by testing the activity of fumarylacetoacetate hydrolase and by DNA analysis, and in amniotic fluid by succinylacetone measurement.
A, Grenier +5 more
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Clinica Chimica Acta, 2006
Hepatorenal tyrosinemia (HT1) is considered a treatable inherited metabolic disease, particularly when detected early in life. Succinylacetone (SA), a unique metabolic marker for HT1, is normally circulating or excreted at very low physiological concentrations and is significantly increased in HT1 patients.We developed and validated a new method for ...
Osama Y, Al-Dirbashi +6 more
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Hepatorenal tyrosinemia (HT1) is considered a treatable inherited metabolic disease, particularly when detected early in life. Succinylacetone (SA), a unique metabolic marker for HT1, is normally circulating or excreted at very low physiological concentrations and is significantly increased in HT1 patients.We developed and validated a new method for ...
Osama Y, Al-Dirbashi +6 more
openaire +2 more sources