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Sucralose metabolism and pharmacokinetics in man
Food and Chemical Toxicology, 2000The metabolic and pharmacokinetic profile of sucralose was studied in human volunteers. Following a single oral dose of (14)C-sucralose (1mg/kg, 100 microCi) to eight male subjects, a mean of 14.5% (range 8.9 to 21.8%) of the radioactivity was excreted in urine and 78.3% (range 69.4 to 89.6%) in the faeces, within 5 days.
A G Renwick
exaly +3 more sources
The pharmacokinetics and metabolism of sucralose in the mouse
Food and Chemical Toxicology, 2000The excretion and metabolism of (14)C-sucralose has been investigated in mice following intravenous and oral administration. A 20mg/kg intravenous dose was rapidly excreted mainly in the urine (80% in 5 days). After 100, 1500 and 3000mg/kg oral doses of (14)C-sucralose, means of 23%, 15% and 16% of the dose, respectively, were excreted in the urine ...
D R Hawkins
exaly +3 more sources
Bioconversion of sucralose-6-acetate to sucralose using immobilized microbial cells
Journal of Molecular Catalysis B: Enzymatic, 2013Abstract Bioconversion of sucralose-6-acetate to sucralose, an artificial sweetener has been carried out using Arthrobacter sp. (ABL) and Bacillus subtilis (RRL-1789) strains isolated at IIIM, Jammu, India. Biotransformation of sucralose-6-acetate to sucralose involves use of microbial whole cells, immobilized whole cells and immobilized whole ...
Pankaj Gupta +2 more
exaly +2 more sources
2013
Sucralose is a nonnutritive, zero-calorie artificial sweetener. It is a chlorinated sugar substitute that is about 600 times as sweet as sucrose. It is produced from sucrose when three chlorine atoms replace three hydroxyl groups. It is consumed as tablets (Blendy) by diabetic and obese patients.
Omar A A, AlDeeb +2 more
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Sucralose is a nonnutritive, zero-calorie artificial sweetener. It is a chlorinated sugar substitute that is about 600 times as sweet as sucrose. It is produced from sucrose when three chlorine atoms replace three hydroxyl groups. It is consumed as tablets (Blendy) by diabetic and obese patients.
Omar A A, AlDeeb +2 more
openaire +2 more sources
Sucralose – An ecotoxicological challenger?
Chemosphere, 2012The non-calorie sweetener sucralose - sucrose containing three chlorine atoms - is intensively sweet and has become a popular substitute for sugar. Its widespread use, exceptional stability in combination with high water solubility have thus resulted in contamination of recipient waters.
Ann-Kristin Eriksson, Wiklund +3 more
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The absence of genotoxicity of sucralose
Food and Chemical Toxicology, 2010Sucralose is a non-nutritive sweetener that is approximately 600 times sweeter than table sugar. It is currently approved for use in over 80 countries. Evidence from chronic studies demonstrates that this compound is not carcinogenic. This report summarizes the results of genotoxicity studies that were part of the original safety assessment of ...
D, Brusick +4 more
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The metabolic fate of sucralose in rats
Food and Chemical Toxicology, 2000The fate of sucralose was investigated in rats following single intravenous or oral doses of 2-1000mg/kg. Following intravenous administration (2-20mg/kg) approximately 80% of the dose was eliminated in urine with 9-16% in the faeces. In contrast, only about 5% of oral doses (10-1000mg/kg) was recovered in the urine, indicating that sucralose is poorly
J, Sims +3 more
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The pharmacokinetics and metabolism of sucralose in the rabbit
Food and Chemical Toxicology, 2000The excretion and metabolism of (14)C-sucralose has been investigated in non-pregnant and pregnant rabbits after administration of single 10mg/kg oral doses. Means of 22% and 55% of the dose were excreted in urine and faeces, respectively, by non-pregnant animals during 5 days.
B A, John, S G, Wood, D R, Hawkins
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Sucralose Destabilization of Protein Structure
The Journal of Physical Chemistry Letters, 2015Sucralose is a commonly employed artificial sweetener that behaves very differently than its natural disaccharide counterpart sucrose in terms of its interaction with biomolecules. The presence of sucralose in solution is found to destabilize the native structure of two model protein systems: the globular protein bovine serum albumin and an enzyme ...
Lee, Chen +5 more
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The Influence of Sucralose on Bacterial Metabolism
Journal of Dental Research, 1990Sucralose (1',4',6' trideoxy-trichloro-galactosucrose) is a nontoxic, intensely sweet sucrose derivative that has been shown to be non-cariogenic in experimental animals. The purpose of this study was to determine whether certain oral bacteria could utilize sucralose.
D A, Young, W H, Bowen
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