Results 91 to 100 of about 42,377 (214)
Optimization of novel compounds using computer‐aided drug design for treatment of cardiac arrhythmia
British Journal of Pharmacology, EarlyView.Background and Purpose Loss‐of‐function mutations of the voltage‐gated Kv7.1 (KCNQ/KCNE1) channels lead to cardiac arrhythmia such as long QT syndrome, characterized by a prolonged QT interval . One strategy to correct the prolonged QT interval is to design molecules that activate KCNQ1/KCNE1 channels and restore the QT interval.
Jessica Jowais +4 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu +10 more
wiley +1 more source
A 6-year experience of CPR outcomes in an emergency department in Thailand
Therapeutics and Clinical Risk Management, 2013 Yuwares Sittichanbuncha,1 Thidathit Prachanukool,1 Kittisak Sawanyawisuth2,31Emergency Medicine Department, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Medicine, Faculty of Medicine, Khon Kaen ...
Sittichanbuncha Y +2 more
doaj
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam +3 more
wiley +1 more source
Visualizing Image Segmentation Network Behavior Through the Lens of Scale Space Analysis
Computer Graphics Forum, EarlyView.Abstract Deep neural networks are widely used for image segmentation, also in sensitive applications such as medical imaging or autonomous driving. However, few explainable AI methods are available that help developers understand such networks beyond classification.
A. C. Mikliss, T. Schultz
wiley +1 more source
European Journal of Philosophy, EarlyView.Abstract It is often said that dignity is the ground of human rights. But what grounds dignity? According to proponents of the metaphysical view, dignity is grounded in our rational capacities, our sense of justice, or a disjunctive list of valuable capacities.
Jordan David Thomas Walters
wiley +1 more source
Response to equine cardiac adverse events during sports
Equine Veterinary Education, EarlyView.Summary Cardiac adverse events and sudden death are a feared scenario for equine veterinarians, with serious consequences for animal health, riders' safety and the social licence to operate equestrian sports. The response to equine cardiac adverse events (CAEs) during sports is poorly defined.
C. Navas de Solis +9 more
wiley +1 more source
Equine Veterinary Education, EarlyView.Summary This case report is of educational value and contributes to the literature because it describes a unique death after anaesthesia due to cardiac tamponade from a rare cardiac neoplasm. In trying to diagnose the origin of chronic sinusitis, a geriatric mule mare was anaesthetised and during recovery, died acutely.
A. Carroll, J. Quandt, S. Dantino
wiley +1 more source
The FEBS Journal, EarlyView.Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy +7 more
wiley +1 more source