Results 101 to 110 of about 42,512 (255)

sGC stimulator BAY 41‐8543 improves survival and ventricular function in a rat model of doxorubicin‐induced cardiomyopathy with nephrotic syndrome

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anthracyclines such as doxorubicin (DOXO) remain a cornerstone of cancer therapy but are associated with a high risk of cardiotoxicity and subsequent heart failure (HF). Impairment of NO/soluble guanylyl cyclase (sGC)/cGMP pathway has been reported in anthracycline‐induced cardiomyopathy.
Olga Gawrys, Petra Škaroupková, Soňa Kikerlová, Zdeňka Vaňourková, Martina Hüttl, Olga Lenčová, Kasin Yadunandam Anandam, Svenja Stomberg, Sönke Behrends, Barbara Szeiffová Bačová, Matúš Sykora, Lisa Dietz, Peter Sandner, Luděk Červenka, Martin Štěrba   +14 more
wiley   +1 more source

Bruton tyrosine kinase inhibitors and cardiovascular adverse events

British Journal of Pharmacology, EarlyView.
Abstract Bruton tyrosine kinase inhibitors (BTKi) have transformed the management of chronic lymphocytic leukaemia and other B‐cell malignancies, yet their therapeutic benefit is tempered by clinically relevant cardiovascular toxicities (predominantly atrial fibrillation, hypertension, bleeding and ventricular arrhythmias).
Massimiliano Camilli, Cristina Madaudo, Emanuela Salvatorelli, Giorgio Minotti, Pierantonio Menna   +4 more
wiley   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

Visualizing Image Segmentation Network Behavior Through the Lens of Scale Space Analysis

Computer Graphics Forum, EarlyView.
Abstract Deep neural networks are widely used for image segmentation, also in sensitive applications such as medical imaging or autonomous driving. However, few explainable AI methods are available that help developers understand such networks beyond classification.
A. C. Mikliss, T. Schultz
wiley   +1 more source

A 6-year experience of CPR outcomes in an emergency department in Thailand

Therapeutics and Clinical Risk Management, 2013
Yuwares Sittichanbuncha,1 Thidathit Prachanukool,1 Kittisak Sawanyawisuth2,31Emergency Medicine Department, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Medicine, Faculty of Medicine, Khon Kaen ...
Sittichanbuncha Y, Prachanukool T, Sawanyawisuth K   +2 more
doaj  

How Common Is Hypercortisolism in Patients With Hypertension? Risk Factors, Epidemiology, and Making a Diagnosis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Endogenous hypercortisolism (EHC) is an underrecognised and clinically significant contributor to hypertension, particularly resistant hypertension. Once viewed as a rare entity, EHC is now understood as a spectrum of cortisol excess associated with adverse cardiometabolic outcomes and target‐organ damage.
Omar Al Dhaybi, Deepak L. Bhatt
wiley   +1 more source

Love and the Basis of Dignity

European Journal of Philosophy, EarlyView.
Abstract It is often said that dignity is the ground of human rights. But what grounds dignity? According to proponents of the metaphysical view, dignity is grounded in our rational capacities, our sense of justice, or a disjunctive list of valuable capacities.
Jordan David Thomas Walters
wiley   +1 more source

Response to equine cardiac adverse events during sports

Equine Veterinary Education, EarlyView.
Summary Cardiac adverse events and sudden death are a feared scenario for equine veterinarians, with serious consequences for animal health, riders' safety and the social licence to operate equestrian sports. The response to equine cardiac adverse events (CAEs) during sports is poorly defined.
C. Navas de Solis, J. Keen, A. Decloedt, B. Delvescovo, K. Hopster, K. Mitchell, J. Slack, G. van Loon, G. Van Steenkiste, L. Nath   +9 more
wiley   +1 more source

Acute and sudden death secondary to cardiac tamponade during anaesthetic recovery in a 21‐year‐old draught mule

Equine Veterinary Education, EarlyView.
Summary This case report is of educational value and contributes to the literature because it describes a unique death after anaesthesia due to cardiac tamponade from a rare cardiac neoplasm. In trying to diagnose the origin of chronic sinusitis, a geriatric mule mare was anaesthetised and during recovery, died acutely.
A. Carroll, J. Quandt, S. Dantino
wiley   +1 more source

A multicentre evaluation of cardiovascular risk prediction tools in people living with HIV across England (ECARTH study)

HIV Medicine, EarlyView.
Abstract Introduction It remains unclear which cardiovascular disease (CVD) risk scores are optimized for people living with treated HIV with high rates of viral suppression. We evaluated the performance of commonly used CVD risk scores in a population of primarily well‐treated HIV patients in England.
Ming Jie Lee, Ashley Murray, Colette Smith, Zakee Abdi, Alastair Duncan, Ellen Dwyer, Mark Gompels, Merle Henderson, Margaret Johnson, Frances Lander, Gavin Manmathan, Jonathan Mok, Nnenna Ngwu, Coral Pratt, Iain Reeves, Razan Saman, Alice Sharp, Eleanor Taylor, Jhia Jiat Teh, Richard Stevens, Thomas R. Fanshawe, Jienchi Dorward, Ranjababu Kulasegaram, Anthony S. Wierzbicki   +23 more
wiley   +1 more source