Results 171 to 180 of about 87,107 (345)

Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Mavacamten (MAVA) is a novel small molecule inhibitor of cardiac myosin, mitigating cardiomyocyte hypercontractility in patients with hypertrophic obstructive cardiomyopathy (HOCM). Despite its recent approval for clinical use, the transcriptional and functional impacts of MAVA remain not well understood.
Elisa Kiselev   +36 more
wiley   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

open access: yesBritish Journal of Pharmacology, EarlyView.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez   +13 more
wiley   +1 more source

DH-452784-4 AN ELECTROCARDIOGRAPHY-BASED DEEP LEARNING ALGORITHM FOR IDENTIFICATION OF INDIVIDUALS AT INCREASED RISK OF SUDDEN CARDIAC ARREST [PDF]

open access: bronze, 2023
Lauri Holmström   +8 more
openalex   +1 more source

Efficacy and safety of switching basal insulin to insulin glargine 300 U/mL in individuals with inadequately controlled type 2 diabetes on advanced insulin therapies: The Toujeo‐Neo T2DM study

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims This real‐world study evaluated the effectiveness and safety of switching basal insulin (BI) to insulin glargine 300 U/mL (Gla‐300) in adults with inadequately controlled type 2 diabetes mellitus (T2DM), previously receiving basal‐supported oral therapy plus prandial insulin (BOTplus) or multiple (≥3) daily injections (MDI) of short ...
Stefan Pscherer   +6 more
wiley   +1 more source

Sudden cardiac arrest in a patient with epilepsy induced by chronic inflammation on the cerebral surface.

open access: green, 2012
Yuxi Liu   +4 more
openalex   +1 more source

Efficacy of telemedicine on glycaemic control in nursing home residents with type 2 diabetes on basal‐bolus insulin therapy: A randomised controlled trial

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Management of insulin therapy in elderly individuals with type 2 diabetes (T2D) residing in nursing homes is often challenging due to comorbidities, cognitive impairment and limited access to specialist care. Continuous glucose monitoring (CGM) and telemedicine may help optimise glycaemic control in this vulnerable population.
Ilaria Dicembrini   +11 more
wiley   +1 more source

Favourable cost-benefit in an early defibrillation program using dual dispatch of ambulance and fire services in out-of-hospital cardiac arrest [PDF]

open access: yes
Aims: Out-of-hospital cardiac arrest (OHCA) is fatal without treatment and time to defibrillation is an extremely important factor in relation to survival.
Hollenberg, Jacob   +3 more
core  

Knowledge, Attitude and Practice in Anxiety, Pain and Medical Emergency Management: A National Survey on 232 Italian Dental Students

open access: yesEuropean Journal of Dental Education, EarlyView.
ABSTRACT Background Anxiety, pain and medical emergencies are crucial concepts in the dental field. Dental students need training, but little is known of their competence on these topics. Aim The aim of this study was to assess the current state of Italian dental students' preparation for, attitudes to, and perceptions of medical emergency, anxiety and
Niccolò Giuseppe Armogida   +6 more
wiley   +1 more source

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