Linkage Evidence for a Two-Locus Inheritance of LQT-Associated Seizures in a Multigenerational LQT Family With a Novel KCNQ1 Loss-of-Function Mutation [PDF]
, 2019 Mutations in several genes encoding ion channels can cause the long-QT (LQT) syndrome with cardiac arrhythmias, syncope and sudden death. Recently, mutations in some of these genes were also identified to cause epileptic seizures in these patients, and
Gessner, Guido +7 more
core +2 more sources
Risk stratification of sudden cardiac death in subjects with asymptomatic ventricular preexcitation: diagnostic value of non-invasive and invasive methods [PDF]
, 2022 Daniela Chilabert +7 more
openalex +1 more source
Concentration–QTc Modeling to Support Clinical Development of Fezolinetant
Clinical Pharmacology in Drug Development, EarlyView.Abstract Fezolinetant is a non‐hormonal, selective neurokinin‐3 receptor antagonist that blocks neurokinin B activation of kisspeptin/neurokinin B/dynorphin neurons to thereby modulate neuronal activity in the thermoregulatory center. Fezolinetant has been approved in many regions, including North America, Europe, Asia, and Australia for the treatment ...
Jace C. Nielsen +6 more
wiley +1 more source
Sudden Cardiac Death with Clozapine and Lorazepam Combination [PDF]
, 2012 Objective: To report a case of sudden cardiac death in a patient taking a combination of clozapine and lorazepam. Case summary: A 31-year-old white man with schizophrenia was found dead at his apartment.
Bhatia, Subhash C. +4 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Potential adverse drug events can be signaled in Clinical Decision Support Systems (CDSSs). This study validated a Swedish CDSS (Janusmed Risk Profile) by investigating associations between calculated risk classifications of drugs with QT‐prolonging potential and registered related clinical outcomes.
Ola Nordqvist +6 more
wiley +1 more source
PO-03-207 BUILDING A PREDICTION MODEL FOR SUDDEN CARDIAC DEATH IN A GENERAL POPULATION IN TAIWAN USING THE MACHINE LEARNING TECHNIQUE [PDF]
, 2023 Yun-Yu Chen +6 more
openalex +1 more source
Major Adverse Cardiac Events with Ondansetron: A Systematic Review
Clinical Pharmacology &Therapeutics, EarlyView.Evidence base: 170 randomized trials, 23,421 adults, predominantly single‐dose IV ondansetron, mean follow‐up 20 days. Observed outcomes: Major adverse cardiac events were rare, no ventricular arrhythmias or torsades de pointes observed. Conclusion: Ondansetron was not associated with increased mortality or serious cardiac arrhythmias in adult ...
Michael Cristian Garcia +11 more
wiley +1 more source
Sudden cardiac death in patients with ischemic heart failure undergoing coronary artery bypass grafting results from the STICH randomized clinical trial (Surgical Treatment for Ischemic Heart Failure) [PDF]
, 2017 Background—The risk of sudden cardiac death (SCD) in patients with heart failure following CABG has not been examined in a contemporary clinical trial of surgical revascularization. This analysis describes the incidence, timing and clinical predictors of
Al-Khatib, Sana M. +19 more
core +2 more sources
Why We Do Not Recommend That People With High‐Risk Smoldering Myeloma Receive Treatment
American Journal of Hematology, EarlyView.
Ghulam Rehman Mohyuddin +3 more
wiley +1 more source