Results 291 to 300 of about 261,206 (349)

Baseline and 10-year change in the number of ideal cardiovascular health metrics and sudden cardiac death in the community. [PDF]

Europace
Empana JP, Perier MC, Warming PE, Marijon E, van Valkengoed I, Ågesen FN, Prescott E, Jabbari R, Climie RE, Elders P, Blom MT, Schwartz PJ, Tan HL, Tfelt-Hansen J, Jouven X.   +14 more
europepmc   +1 more source

Late‐onset multiple system atrophy: Neuropathological features associated with slow disease progression

Brain Pathology, EarlyView.
Late‐onset multiple system atrophy (LO‐MSA; onset ≥75 years) shows milder degeneration of the striatonigral and olivopontocerebellar systems and serotonergic neurons in the ventrolateral medulla than usual‐age‐onset MSA with a similar disease duration. LO‐MSA may therefore exhibit slower pathological progression.
Misato Ozawa, Rie Saito, Takuya Konno, Yasuko Kuroha, Tetsuhiko Ikeda, Akio Yokoseki, Takashi Tani, Tomoe Sato, Jiro Idezuka, Reiji Koide, Shigeru Fujimoto, Osamu Onodera, Mari Tada, Akiyoshi Kakita   +13 more
wiley   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Magnetocardiography in the Evaluation of Sudden Cardiac Death Risk: A Systematic Review. [PDF]

Ann Noninvasive Electrocardiol
Lachlan T, He H, Kusano K, Aiba T, Brisinda D, Fenici R, Osman F.   +6 more
europepmc   +1 more source

Rescue of loss‐of‐function long QT syndrome‐associated mutations in KV7.1/KCNE1 by the endocannabinoid N‐arachidonoyl‐L‐serine (ARA‐S)

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Congenital long QT syndrome (LQTS) involves genetic mutations affecting ion channels, leading to a prolonged QT interval and increased risk of potentially lethal ventricular arrhythmias. Mutations in the genes encoding KV7.1/KCNE1 are the most frequent, with channel loss‐of‐function contributing to LQTS.
Irene Hiniesto‐Iñigo, Akshay Sridhar, Julien Louradour, Alicia De la Cruz, Siri Lundholm, Amaia Jauregi‐Miguel, Federica Giannetti, Luca Sala, Katja E. Odening, H. Peter Larsson, Nina E. Ottosson, Sara I. Liin   +11 more
wiley   +1 more source

Risk Factors and Genetic Insights into Coronary Artery Disease-Related Sudden Cardiac Death: A Molecular Analysis of Forensic Investigation. [PDF]

Int J Mol Sci
He X, Li L, Zhou D, Yan Z, Liu M, Yun L.
europepmc   +1 more source

Matrix metalloproteinase inhibition protects against junctophilin‐2 proteolysis during doxorubicin‐induced cardiotoxicity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Treatment of cancer patients with anthracyclines is known to cause dose‐dependent cardiotoxicity through several mechanisms including enhanced oxidative stress, ultimately resulting in defective excitation–contraction coupling.
Wesam Bassiouni, Brandon Y. H. Chan, Andrej Roczkowsky, Joshua W. Kranrod, Zabed Mahmud, Joseph O. Primeau, Woo Jung Cho, Howard S. Young, John M. Seubert, Richard Schulz   +9 more
wiley   +1 more source

Age and Sex Differences in the Risk of Sudden Cardiac Death in Patients with Hypertrophic Cardiomyopathy: A Multi-Centre Cohort Study. [PDF]

Vasc Health Risk Manag
Ma H, Xu F, Liu L, Pan C, Luo R, Liu M, Liu T, Shu Y, Li X.   +8 more
europepmc   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Heritability of sudden cardiac death in Thoroughbred racehorses. [PDF]

Equine Vet J
Kapusniak A, Nath L, Hebart M, Franklin S.   +3 more
europepmc   +1 more source