Results 41 to 50 of about 259,314 (347)

Consensus of state of the art mortality prediction models: From all-cause mortality to sudden death prediction [PDF]

arXiv, 2023
Worldwide, many millions of people die suddenly and unexpectedly each year, either with or without a prior history of cardiovascular disease. Such events are sparse (once in a lifetime), many victims will not have had prior investigations for cardiac disease and many different definitions of sudden death exist.
arxiv  

Defibrillation via the Elimination of Spiral Turbulence in a Model for Ventricular Fibrillation [PDF]

Physical Review Letters, Vol. 86, 3678-3681 (2001), 2001
Ventricular fibrillation, the major reason behind sudden cardiac death, is turbulent cardiac electrical activity in which rapid, irregular disturbances in the spatiotemporal electrical activation of the heart makes it incapable of any concerted pumping action.
arxiv   +1 more source

Evaluation of Deutetrabenazine's Potential to Delay Cardiac Repolarization Using Concentration‐QTc Analysis

Clinical Pharmacology in Drug Development, Volume 12, Issue 1, Page 94-106, January 2023., 2023
Abstract Deutetrabenazine (Austedo) is indicated in adults for chorea associated with Huntington disease and tardive dyskinesia. Escalating deutetrabenazine doses were administered to healthy volunteers who were cytochrome P450 2D6 extensive/intermediate metabolizers (EMs) or poor metabolizers (PMs) to determine pharmacokinetic exposure of parent drug ...
Frank Schneider, Borje Darpo, Pippa S. Loupe, Hongqi Xue, Helena Knebel, Maria Gutierrez, Mark Forrest Gordon, Laura Rabinovich‐Guilatt   +7 more
wiley   +1 more source

Myocardial fibrosis in stroke survivors [PDF]

, 2015
Stroke survivors are most likely to die of cardiac death, yet few undergo comprehensive cardiac assessment to look for reversible causes. Myocardial fibrosis (MF) is not only the hallmark of cardiomyopathy, but also a substrate for sudden cardiac death ...
Allgar, V., MacWalter, R., McSwiggan, S., Struthers, A. D., Sze, S., Wong, K., Wong, S.   +6 more
core   +1 more source

A novel approach for the diagnosis of ventricular tachycardia based on phase space reconstruction of ECG [PDF]

International Journal of Cardiology, Volume 172, Issue 1, March 2014, Pages e31-e33, 2014
Ventricular arrhythmias comprise a group of disorders which manifest clinically in a variety of ways from ventricular premature beats (VPB) and no sustained ventricular tachycardia (in healthy subjects) to sudden cardiac death due to ventricular tachyarrhythmia in patients with and/or without structural heart disease.
arxiv   +1 more source

Clinical Relevance of Drug–Drug Interactions With Antibiotics as Listed in a National Medication Formulary: Results From Two Large Population‐Based Case‐Control Studies in Patients Aged 65–100 Years Using Linked English Primary Care and Hospital Data

Clinical Pharmacology &Therapeutics, Volume 113, Issue 2, Page 423-434, February 2023., 2023
This study evaluated drug–drug interactions (DDIs) between antibiotic and nonantibiotic drugs listed with warnings of severe outcomes in the British National Formulary based on adverse drug reaction (ADR) detectable with routine International Classification of Diseases, Tenth Revision coding.
Tjeerd Pieter van Staa, Munir Pirmohamed, Anita Sharma, Iain Buchan, Darren M. Ashcroft   +4 more
wiley   +1 more source

Is there a utility for QRS dispersion in clinical practice? [PDF]

, 2017
Prognostic markers derived from standard ECG have always been seductive. Increased dispersion of durations of the P wave, of the QRS complex, or of the QT interval has been associated with the risk of atrial fibrillation, ventricular arrhythmias, sudden ...
Chávez-González, Elibet, Donoiu, Ionuț, Târtea, Georgică Costinel   +2 more
core   +4 more sources

Brugada Syndrome and GPD1L: Definite Genotype-Phenotype Association?

Cardiogenetics
The GPD1L gene encodes a small cytoplasmic protein that is involved in the regulation of sodium currents. Alterations in this gene have been associated with Brugada syndrome.
Andrea Greco, Estefanía Martínez-Barrios, José Cruzalegui, Sergi Cesar, Fredy Chipa, Nuria Díez-Escuté, Patricia Cerralbo, Irene Zschaeck, Paula Loredo, Georgia Sarquella-Brugada, Oscar Campuzano   +10 more
doaj   +1 more source

Sudden cardiac death—update [PDF]

International Journal of Legal Medicine, 2020
AbstractSudden cardiac death (SCD) is one of the most common causes of death worldwide with a higher frequency especially in the young. Therefore, SCD is represented frequently in forensic autopsy practice, whereupon pathological findings in the heart can explain acute death.
P. Markwerth, T Bajanowski, I. Tzimas, R. Dettmeyer   +3 more
openaire   +2 more sources

Development in Prescriptions of Contraindicated and Potentially Harmful QT Interval–Prolonging Drugs in a Large Geriatric Inpatient Cohort From 2011 to 2021

Clinical Pharmacology &Therapeutics, Volume 113, Issue 2, Page 435-445, February 2023., 2023
Regulatory authorities put major emphasis on QT (interval)–prolonging properties of new molecular entities. Product information/Summaries of Product Characteristics (SmPCs) of multiple drugs contain warnings or contraindications regarding QT prolongation, e.g., on coadministration of QT‐prolonging drugs (QT drugs).
Melanie I. Then, Thomas Tümena, Anna Sledziewska, Karl‐Günter Gaßmann, Renke Maas, Martin F. Fromm   +5 more
wiley   +1 more source