Results 91 to 100 of about 23,186 (272)

Efficacy and tolerability of perampanel as add‐on therapy in Dravet syndrome: A prospective real‐world study

Epilepsia Open, EarlyView.
Abstract Objective To investigate the efficacy and tolerability of perampanel (PER) on Dravet syndrome in China by a prospective real‐world study. Methods We prospectively enrolled children with Dravet syndrome from the neurology clinic of Shenzhen Children's Hospital from September 2020 to October 2021.
Han Wang, Hong Chen, Xin Ding, Xueyan Cao, Jiahui Mai, Huafang Zou, Dongfang Zou, Yanwei Zhu, Jianxiang Liao, Dezhi Cao   +9 more
wiley   +1 more source

Rest‐activity rhythm phenotypes in adults with epilepsy and intellectual disability

Epilepsia Open, EarlyView.
Abstract Objective Rest‐activity rhythms (RARs) are perturbed in many forms of neuropsychiatric illness. In this study, we applied wrist actigraphy to describe RAR perturbations in intellectually disabled adults with epilepsy (“E + ID”), using a cross‐sectional case–control design.
Nandani Adhyapak, Grace E. Cardenas, Mark A. Abboud, Vaishnav Krishnan   +3 more
wiley   +1 more source

Ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsy. [PDF]

, 2012
We report a case of sustained ventricular tachycardia following the initiation of lacosamide as adjunctive epilepsy treatment. A 49-year-old male with intractable frontal lobe seizures experienced severe ventricular tachycardia following the addition of ...
DeGiorgio, Andrew C, DeGiorgio, Christopher M, Desso, Tamara E, Lee, Lance   +3 more
core   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

Possible role of SCN4A skeletal muscle mutation in apnea during seizure

Epilepsia Open, 2019
SCN4A gene mutations cause a number of neuromuscular phenotypes including myotonia. A subset of infants with myotonia‐causing mutations experience severe life‐threatening episodic laryngospasm with apnea.
Dilşad Türkdoğan, Emma Matthews, Sunay Usluer, Aslı Gündoğdu, Kayıhan Uluç, Roope Mannikko, Michael G. Hanna, Sanjay M. Sisodiya, Hande S. Çağlayan   +8 more
doaj   +1 more source

Sudden unexpected death in children with epilepsy: the many faces of fungal pathogenicity [PDF]

, 2012
Epilepsy is one of the most prevalent neurological diseases worldwide. the mortality rates are considerably higher in people with epilepsy than would be expected in a healthy population and sudden unexpected death in epilepsy (SUDEP) is the most frequent
Andersen, Monica Levy, Cavalheiro, Esper Abrão, Colombo, Arnaldo Lopes, Cysneiros, Roberta Monterazzo, Scorza, Fulvio Alexandre, Tufik, Sergio   +5 more
core   +1 more source

STARDEV Study: Neurodevelopmental Trajectory and Long‐Term Outcomes of Patients with Startle Disease/Hyperekplexia

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Although initial clinical presentation of hyperekplexia/startle disease is well known, data regarding long‐term clinical outcomes is lacking. Objectives We provide a long‐term evaluation from clinical and pharmacological perspectives, focusing on neurodevelopmental trajectory. Methods Twenty‐eight patients from nine French hospitals
Diane Pina, Agathe Roubertie, Marie‐Aude Spitz, Claudia Ravelli, Nadia Bahi‐Buisson, Farha Gheurbi, Marion Buchy, Thomas Loppinet, Nicole Chemaly‐Perin, Marie‐Christine Nougues, Benedicte Heron, Regis Lopez, Mathieu Anheim, Mélanie Fradin, Claude Cances, Justine Avez‐Couturier, Fabienne Dalmon, Gaëtan Lesca, Vincent Des Portes, Laurence Lion‐François   +19 more
wiley   +1 more source

Real‐World Therapeutic Hypothermia for Neonatal HIE: Neurodevelopmental Outcomes and Predictors

Acta Paediatrica, EarlyView.
ABSTRACT Aim This study assessed neurodevelopmental outcomes in neonates with hypoxic‐ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) outside randomised controlled trials (RCTs). It also aimed to identify predictors of outcomes and evaluate TH practices across centres.
Luca Bedetti, Licia Lugli, Isotta Guidotti, Maria Federica Roversi, Elisa Della Casa Muttini, Marisa Pugliese, Natascia Bertoncelli, Eugenio Spaggiari, Alessandra Todeschini, Gina Ancora, Sara Grandi, Giancarlo Gargano, Claudio Gallo, Mario Motta, Piero Catenazzi, Luigi Tommaso Corvaglia, Vittoria Paoletti, Agostina Solinas, Elisa Ballardini, Serafina Perrone, Sabrina Moretti, Marcello Stella, Alberto Berardi, Fabrizio Ferrari   +23 more
wiley   +1 more source

Dentate gyrus abnormalities in sudden unexplained death in infants: morphological marker of underlying brain vulnerability [PDF]

, 2014
Sudden unexplained death in infants, including the sudden infant death syndrome, is likely due to heterogeneous causes that involve different intrinsic vulnerabilities and/or environmental factors.
Armstrong, Dawna D., Cryan, Jane B., Goldstein, Richard D., Haas, Elisabeth A., Haynes, Robin L., Journey, Kelley W., Kinney, Hannah C., Mena, Othon J., Minter, Megan, Paterson, David S., Trachtenberg, Felicia L.   +10 more
core   +1 more source

Update on the Genetic Basis of Sudden Unexpected Death in Epilepsy [PDF]

International Journal of Molecular Sciences, 2019
Epilepsy is a common neurological disorder associated with increased morbidity and mortality. Sudden unexpected death in epilepsy, also known as SUDEP, is the main cause of death in patients with epilepsy. SUDEP has an incidence of 1.2 per 1000 person-years in adults and 0.2 per 1000 person-years in children.
Coll M., Oliva A., Grassi S., Brugada R., Campuzano O.   +4 more
openaire   +4 more sources