Results 121 to 130 of about 22,016 (288)

Comparison of Antiepileptic Drug Levels in Sudden Unexpected Deaths in Epilepsy with Deaths from Other Causes [PDF]

, 1999
Ken Opeskin, Michael Burke, Stephen Cordner, Samuel F. Berkovic   +3 more
openalex   +1 more source

How often do caregivers attend their child when a seizure detection device alerts for a nocturnal major motor seizure?

Epilepsia, EarlyView.
Abstract Objective Development in seizure detection devices has focused mainly on detection performance. Yet, in order to serve their function in preventing harmful situations and even sudden unexpected death in epilepsy (SUDEP), caregivers need to respond to seizure alarms. This aspect has not been studied so far.
Anemoon T. Bosch, Franciscus S. S. Leijten, Roland D. Thijs   +2 more
wiley   +1 more source

Prolactin Levels in Sudden Unexpected Death in Epilepsy [PDF]

, 2000
Kenneth Opeskin, Iain J. Clarke, Samuel F. Berkovic   +2 more
openalex   +1 more source

Comorbidities in the mouse model of temporal lobe epilepsy induced by intrahippocampal kainate

Epilepsia, EarlyView.
Abstract Objective Mesial temporal lobe epilepsy (MTLE) is generally associated with cognitive and psychiatric comorbidities. Here we examined whether similar comorbidities are observed in mice injected with kainate in the dorsal hippocampus, a model known to recapitulate many features of human MTLE, and if these comorbidities are sex dependent ...
Loan Samalens, Camille Beets, Clothilde Courivaud, Philippe Kahane, Antoine Depaulis   +4 more
wiley   +1 more source

Sudden unexpected death in epilepsy: a series of witnessed deaths [PDF]

, 2000
Yvonne Langan
openalex   +1 more source

Electrical stimulation of stem cell–derived human neural networks for evaluating anti‐seizure medications

Epilepsia, EarlyView.
Abstract Objective Current preclinical epilepsy drug screening relies on animal models that poorly reflect human neurophysiology, leading to high failure rates in clinical translation. We aimed to establish a human in vitro model using human‐induced pluripotent stem cell (hiPSC)–derived cortical neurons cultured on multielectrode arrays (MEAs), capable
Joshua Nicholls, Jinchao Gu, Zhibin Chen, Zikou Liu, Ana Antonic‐Baker, Muhammad Shahid Javaid, Eliza Moore, Hailin Zhu, Afaf Altalhi, David K. Wright, Huseyin Sumer, Terence J. O'Brien, Patrick Kwan, Ben Rollo   +13 more
wiley   +1 more source

Long‐term survival after adult epilepsy surgery: Mortality and predictors in a large cohort

Epilepsia, EarlyView.
Abstract Objective Long‐term survival data in adults undergoing surgery for drug‐resistant focal epilepsy remain limited. We examined mortality patterns and predictors in a large cohort followed for over 30 years. Methods Adults who underwent epilepsy surgery (1990–2022) were analyzed.
Giorgio Fiore, Jane de Tisi, Aidan O'Keeffe, Anna Miserocchi, Andrew W. McEvoy, Josemir W. Sander, John S. Duncan   +6 more
wiley   +1 more source

What matters most to people living with epilepsy? A rapid review of qualitative research relating to health outcomes

Epilepsia, EarlyView.
Abstract At present, the outcomes measured and reported in clinical trials for adults with epilepsy are heterogenous and have often not been selected in consultation with people living with epilepsy. As part of a wider project developing a core outcome set for clinical trials for adults with epilepsy (the EPSET Project), a rapid review of the published
James W. Mitchell, John Doherty, Rachel Batchelor, Adam Noble, Anthony Marson   +4 more
wiley   +1 more source

Left atrial remodeling in epilepsy: A comparative echocardiographic study of left atrial emptying fraction and left atrial volumetric index in patients with epilepsy

Epilepsia, EarlyView.
Abstract Objective Patients with epilepsy (PWE) are at increased risk for cardiac abnormalities, including arrhythmias, structural changes, and sudden unexpected death in epilepsy (SUDEP). Although previous studies have examined ventricular dysfunction, left atrial (LA) structural and mechanical changes remain underexplored.
Selcen Duran, Yalcin Boduroglu
wiley   +1 more source

Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies

Epilepsia, EarlyView.
Abstract Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease‐targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second‐generation drug candidates ...
Heidrun Potschka, Daniel Pérez‐Pérez
wiley   +1 more source