Results 61 to 70 of about 6,328 (179)

Altered ventilatory responses to hypercapnia-hypoxia challenges in a preclinical SUDEP model involve orexin neurons

Neurobiology of Disease
Failure to recover from repeated hypercapnia and hypoxemia (HH) challenges caused by severe GCS and postictal apneas may contribute to sudden unexpected death in epilepsy (SUDEP).
Shruthi H. Iyer, Jillian E. Hinman, Ted Warren, Stephanie A. Matthews, Timothy A. Simeone, Kristina A. Simeone   +5 more
doaj   +1 more source

SUDEP and mortality in developmental and epileptic encephalopathies: A meta‐analysis of randomized clinical trials and extension studies

Epilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are associated with high premature mortality and increased risk of sudden unexpected death in epilepsy (SUDEP). However, epidemiological data remain limited, particularly for specific syndromes such as Dravet syndrome (DS), Lennox–Gastaut syndrome (LGS), and infantile epileptic ...
Pierludovico Moro, Maria Sole Borioni, Adolfo Mazzeo, Enrico Cocchi, Carlo Di Bonaventura, Emanuele Cerulli Irelli   +5 more
wiley   +1 more source

Sudden, unexpected death in epilepsy in children

Seizure, 1997
Sudden, unexpected death in epilepsy (SUDEP) remains a controversial and enigmatic syndrome, particularly in children where the incidence, prevalence and risk factors may, and probably do, differ from adults. This study demonstrates (and further reinforces) the difficulties and inability of retrospective and coroner/death certificate-derived data in ...
openaire   +2 more sources

Effect of time to palliative epilepsy surgery on outcomes

Epilepsia, EarlyView.
Abstract Objective Epilepsy duration is a modifiable risk factor in the outcome of definitive epilepsy surgery; however, an analogous effect in palliative procedures has not been shown. We reviewed the Pediatric Epilepsy Surgery Database data for an association between epilepsy duration and seizure reduction in palliative procedures.
Robert M. Crutcher, David E. Horvat, Avery R. Caraway, Kristen H. Arredondo, Taylor J. Abel, Nitin Agarwal, Allyson L. Alexander, Dallas Michael Armstrong, Kurtis I. Auguste, Danilo Bernardo, Jeffrey Bolton, David Bonda, Dewi Frances Depositario‐Cabacar, Krista Eschbach, William D. Gaillard, Aran Groves, Jason S. Hauptman, Pradeep K. Javarayee, Cemal Karakas, Andrew T. Knox, Jenny J. Lin, Patricia E. McGoldrick, Derryl J. Miller, Edward John Novotny, Adam P. Ostendorf, Pilar D. Pichon, Shilpa B. Reddy, Debopam Samanta, Rani K. Singh, Janelle L. Wagner, Steven M. Wolf, Lily C. Wong‐Kisiel, Fernando N. Galan, M. Scott Perry, Michael A. Ciliberto   +34 more
wiley   +1 more source

MEDICOLEGAL AND ETHICAL ASPECTS OF A DEATH CASE DUE TO EPILEPSY: CLINICAL CASE, CLINICAL FORENSICS, OR FORENSIC PATHOLOGY?

Jurnal Kedokteran Diponegoro
Background: An unwitnessed death in a man with epilepsy, found in a bathroom with a head injury and immersion, raises key clinical and forensic concerns.
Adji Suwandono, Hedva Rayna Hitipeuw, Funica Asri Rachmawaty, Sandy Adi Nugraha Pratama, Alfonsus Aryo Sunu Bakti   +4 more
doaj   +1 more source

Cardiovascular events and mortality in adults with late onset seizures: Focus on enzyme‐modulating antiseizure medications

Epilepsia, EarlyView.
Abstract Objective Using a Dutch insurance claims registry, we examine whether people with epilepsy have an increased risk of major ischemic cardiovascular events or death compared to people without epilepsy. We also assess whether this risk differs between users of enzyme‐modulating and non‐enzyme‐modulating antiseizure medications (ASMs).
Paola Vassallo, Nathan A. Shlobin, Mark R. Keezer, Roland D. Thijs, Ley Sander   +4 more
wiley   +1 more source

Association of hyperventilation-induced heart rate variability and sudden unexpected death in epilepsy in drug-resistant epilepsy

Arquivos de Neuro-Psiquiatria
Background Within the general epilepsy population, the incidence of Sudden Unexpected Death in Epilepsy (SUDEP) ranges from approximately 0.35 to 2.3 per 1,000 individuals per year.
Demet Ilhan Algin, Oguz Erdinc
doaj   +1 more source

Are Variants Causing Cardiac Arrhythmia Risk Factors in Sudden Unexpected Death in Epilepsy?

Frontiers in Neurology, 2020
Sudden unexpected death in epilepsy (SUDEP) is the most common cause of premature mortality in individuals with epilepsy. Acute and adaptive changes in heart rhythm in epilepsy implicate cardiac dysfunction as a potential pathogenic mechanism in SUDEP ...
Lauren E. Bleakley, Ming S. Soh, Richard D. Bagnall, Richard D. Bagnall, Lynette G. Sadleir, Samuel Gooley, Christopher Semsarian, Christopher Semsarian, Ingrid E. Scheffer, Ingrid E. Scheffer, Ingrid E. Scheffer, Samuel F. Berkovic, Christopher A. Reid   +12 more
doaj   +1 more source

Ventral anterior thalamic dysfunction distinguishes seizure generalization in temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Focal‐to‐bilateral tonic–clonic seizures (FBTCS) in temporal lobe epilepsy (TLE) involve thalamocortical networks, yet the functional integrity and role of specific thalamic subregions in seizure generalization remain unclear. In this cross‐sectional study, we investigated whether thalamic subregion functional connectivity patterns ...
Stacy N. Hudgins, Michael R. Sperling, Hasan Ayaz, Joseph I. Tracy   +3 more
wiley   +1 more source

Comparative assessment of artificial intelligence chatbots' performance in responding to healthcare professionals' and caregivers' questions about Dravet syndrome

Epilepsia Open, EarlyView.
Abstract Objective Artificial intelligence chatbots have been a game changer in healthcare, providing immediate, round‐the‐clock assistance. However, their accuracy across specific medical domains remains under‐evaluated. Dravet syndrome remains one of the most challenging epileptic encephalopathies, with new data continuously emerging in the ...
Joana Jesus‐Ribeiro, Eugenia Roza, Bárbara Oliveiros, Joana Barbosa Melo, Mar Carreño   +4 more
wiley   +1 more source