Results 61 to 70 of about 7,553 (218)

Epilepsy and hypertension: The possible link for sudden unexpected death in epilepsy?

Cardiology Journal, 2021
Epilepsy affects about 50 million people worldwide. Sudden unexpected death in epilepsy (SUDEP) is the main cause of death in epilepsy accounting for up to 17% of all deaths in epileptic patients, and therefore remains a major public health problem ...
Patrycja J. Szczurkowska, Katarzyna Polonis, Christiane Becari, Michał Hoffmann, Krzysztof Narkiewicz, Marzena Chrostowska   +5 more
doaj   +1 more source

Cardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency

Epilepsia, EarlyView.
Abstract Objective Some ion channel genes linked to developmental and epileptic encephalopathy (DEE) are also linked to cardiac arrhythmia, leading to the hypothesis that predisposition to cardiac arrhythmias may contribute to the complex disease presentation of DEE and possibly to the mechanism of sudden unexpected death in epilepsy.
Roberto Ramos‐Mondragon, Shuyun Wang, Qinghua Liu, Chunling Chen, Alexander M. Greiner, Abigail M. Marx, Maya Shih, Jack M. Parent, Barry London, Lori L. Isom   +9 more
wiley   +1 more source

Does the lunar phase have an effect on sudden unexpected death in epilepsy?

, 2009
The incidence of sudden unexpected death in epilepsy (SUDEP) in Our epilepsy unit over an 8-year period was analyzed to determine a possible association between phase of the moon and SUDEP.
Scorza, Carla A. [UNIFESP], Scorza, Fulvio A. [UNIFESP], CAVALHEIRO, Esper A., Arida, Ricardo M. [UNIFESP], SCORZA, Carla A., SAKAMOTO, Americo C., TERRA-BUSTAMANTE, Vera C., ALBUQUERQUE, Marly de, MACHADO, Helio R., Albuquerque, Marly de [UNIFESP], Cavalheiro, Esper A. [UNIFESP], ARIDA, Ricardo M., SCORZA, Fulvio A.   +12 more
core   +1 more source

Dual role of spreading depolarization in an epileptic focus

Epilepsia, EarlyView.
Abstract Objective Spreading depolarizations (SDs) are often associated with epileptic discharges. Although SDs are traditionally thought to contribute to postictal depression and termination of epileptic discharges, seizures may also occur during SDs or may even follow SDs, suggesting that interactions between SD and seizures are more complex.
Daria Vinokurova, Karina Tukhvatullina, Roustem Khazipov, Azat Nasretdinov   +3 more
wiley   +1 more source

Management of ring chromosome 20 syndrome: Narrative review and consensus recommendations

Epilepsia, EarlyView.
Abstract Ring chromosome 20 (ring 20) is a rare genetic condition usually presenting as developmental and epileptic encephalopathy. The disease is caused by fusion of the long and short arms of chromosome 20. Patients are symptomatic even if there is no loss of genetic material.
Asma Khamis, Emilia Ricci, Maria Paola Canevini, Lieven Lagae, Kentaro Tokumoto, Yushi Inoue, Tim Buckinx, Allison Watson, Kenneth A. Myers   +8 more
wiley   +1 more source

Listening across frequencies: Capturing seizures of all patients to advance antiseizure medication development

Epilepsia, EarlyView.
Abstract Seizure frequency has been the primary endpoint in epilepsy trials, with enrollment usually requiring ≥4 seizures per month. This threshold is more and more misaligned with clinical reality, as the availability of more treatment options has reduced baseline seizure burden, with a risk of excluding a proportion of patients from trials. Although
Stéphane Auvin, Jacqueline French
wiley   +1 more source

Sudden unexpected death in epilepsy: from mechanisms to prevention.

, 2006
International audiencePURPOSE OF REVIEW: To discuss the pathophysiology and potential prevention of sudden unexpected death in epilepsy. RECENT FINDINGS: Long-term electrocardiogram monitoring over several months has detected ictal asystole in three out ...
Kahane, Philippe, Ryvlin, Philippe, Montavont, Alexandra   +2 more
core   +1 more source

Possible role of SCN4A skeletal muscle mutation in apnea during seizure

Epilepsia Open, 2019
SCN4A gene mutations cause a number of neuromuscular phenotypes including myotonia. A subset of infants with myotonia‐causing mutations experience severe life‐threatening episodic laryngospasm with apnea.
Dilşad Türkdoğan, Emma Matthews, Sunay Usluer, Aslı Gündoğdu, Kayıhan Uluç, Roope Mannikko, Michael G. Hanna, Sanjay M. Sisodiya, Hande S. Çağlayan   +8 more
doaj   +1 more source

Unravelling the mysteries of sudden unexpected death in epilepsy

Neurología (English Edition), 2019
Introduction: Sudden unexpected death in epilepsy (SUDEP) is the most frequent cause of premature death in epileptic patients. Most SUDEP events occur at night and frequently go unnoticed; the exact pathophysiological mechanisms of this phenomenon ...
K.G. Hampel, R. Rocamora Zuñiga, C.M. Quesada   +2 more
doaj   +1 more source

Effect of epileptogenesis on hypercapnic cardioventilatory response in kainic acid rats

Epilepsia, EarlyView.
Abstract Objective Cardioventilatory failure is the leading mechanism proposed to underlie sudden unexpected death in epilepsy (SUDEP), which occurs predominantly at night in patients with generalized tonic–clonic seizures. Interictal hypercapnic cardioventilatory responses are suggested to be involved, as they are ablated in chronically epileptic ...
Auriane Apaire, Elise Collard, Abigail Niyibizi, Natasha N. Kumar, Enrique Germany Morrison, Javier Chavez Cerda, Ayse S. Dereli, Riem El Tahry   +7 more
wiley   +1 more source