Results 81 to 90 of about 21,823 (231)

The Insula and Its Epilepsies [PDF]

, 2019
Insular seizures are great mimickers of seizures originating elsewhere in the brain. The insula is a highly connected brain structure. Seizures may only become clinically evident after ictal activity propagates out of the insula with semiology that ...
Gonzalez-Martinez, Jorge, Isnard, Jean, Jobst, Barbara C., Kahane, Philippe, Lacuey, Nuria, Lado, Fred, Lahtoo, Samden D., Nguyen, Dang K., Wu, Chengyuan   +8 more
core   +1 more source

Serotonin and sudden unexpected death in epilepsy

Experimental Neurology, 2020
Epilepsy is a highly prevalent disease characterized by recurrent, spontaneous seizures. Approximately one-third of epilepsy patients will not achieve seizure freedom with medical management and become refractory to conventional treatments. These patients are at greatest risk for sudden unexpected death in epilepsy (SUDEP).
Alexandra N. Petrucci, Katelyn G. Joyal, Benton S. Purnell, Gordon F. Buchanan   +3 more
openaire   +3 more sources

Predictors of etiology and drug resistance in children with new‐onset focal seizures

Epilepsia Open, EarlyView.
Abstract Objective To examine the clinical features of new‐onset focal seizures in children and investigate clinical associations and predictors of underlying etiology and drug resistance. Methods Data were gathered from The Children's Hospital at Westmead admissions for patients aged 1 month to 18 years who presented with new‐onset focal seizures ...
Byoung Chan Lee, Russell C. Dale, Elizabeth H. Barnes, Shekeeb S. Mohammad, Sachin Gupta, Chong Wong, Deepak Gill, Kavitha Kothur   +7 more
wiley   +1 more source

Mortalidade em crianças com epilepsia severa: 10 anos de seguimento [PDF]

, 2011
Epilepsy is the main neurological condition in children and adolescents. Unfortunately patients with medical refractory epilepsy are more susceptible for clinical complications and death.
Arida, Ricardo Mario, Fernandes, Regina Maria França, Machado, Helio Rubens, Sakamoto, Américo Ceiki, Scorza, Fulvio Alexandre, Terra, Vera Cristina, Wichert-Ana, Lauro   +6 more
core   +3 more sources

Efficacy and safety of perampanel as first adjunctive therapy in patients with focal‐onset seizures or generalized tonic‐clonic seizures in four post‐marketing studies across regions

Epilepsia Open, EarlyView.
Abstract Objective Early response to anti‐seizure medication (ASM) is associated with a favorable prognosis in patients with epilepsy. Research is required to confirm existing data on the clinical use of perampanel as first adjunctive therapy in different patient groups and different regions.
Stefano Meletti, Vineet Punia, Amitabh Dash, Anna Lisa Gentile, Ricardo Sáinz‐Fuertes, Samantha Goldman, Tobias Goldmann, Anna Patten, Dinesh Kumar, Leock Y. Ngo, Bernhard J. Steinhoff   +10 more
wiley   +1 more source

Linkage Evidence for a Two-Locus Inheritance of LQT-Associated Seizures in a Multigenerational LQT Family With a Novel KCNQ1 Loss-of-Function Mutation [PDF]

, 2019
Mutations in several genes encoding ion channels can cause the long-QT (LQT) syndrome with cardiac arrhythmias, syncope and sudden death. Recently, mutations in some of these genes were also identified to cause epileptic seizures in these patients, and
Gessner, Guido, Heinemann, Stefan H., Prüss, Harald, Rimpau, Wilhelm, Ruppert, Ann-Katrin, Rüschendorf, Franz, Sander, Thomas, Schulz, Herbert   +7 more
core   +2 more sources

Sudden Unexpected Death in Epilepsy: Addressing the Challenges [PDF]

Current Neurology and Neuroscience Reports, 2014
Epilepsy is associated with a higher rate of premature death than the general population, and the commonest cause of epilepsy mortality is sudden unexpected death in epilepsy (SUDEP). It is difficult to quantify because of the variable reporting of this cause of death.
Smithson, W. Henry, Colwell, Brigitte, Hanna, Jane   +2 more
openaire   +3 more sources

Cardiovascular morbidity following epilepsy: A nationwide retrospective cohort study in South Korea

Epilepsia Open, EarlyView.
Abstract Objective This study evaluated the long‐term risk of major cardiovascular diseases (CVDs) in patients with epilepsy using a nationwide cohort, aiming to address critical gaps in population‐based evidence on brain–heart interactions. Methods Data from the Korean National Health Insurance Service (2002–2013) were analyzed.
Youngoh Bae, Chaeyoon Kang, Yejin Lee, Haerim Cho, Hohyun Jung, Seung Won Lee   +5 more
wiley   +1 more source

Treatment of Electrical Storm with Amiodarone in Brugada Syndrome- an Unexpected Protective Effect [PDF]

, 2013
We are reporting on a 53 year old man with proven Brugada syndrome and ICD implantation for resuscitation in context of polymorphic VT. After recurrent arrhythmia he was treated with Amiodarone.
Lambiase, PD, Novak, J
core   +1 more source

Stiripentol use in Dravet syndrome patients in the USA: Results of a real‐world study

Epilepsia Open, EarlyView.
Abstract Objective Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy with a high seizure burden and mortality risk. Stiripentol, one of the first DS‐specific therapies, received FDA approval in 2018 but its real‐world use and impact post‐approval in the USA remain insufficiently characterized.
Elaine Wirrell, James Wheless, Michael Scott Perry, Linda Laux, Karen C. Keough, Julie Ziobro, Aimee F. Luat, Gewalin Aungaroon, Michael A. Ciliberto, Roxane Noel, Laurent Chancharme, Joseph Sullivan   +11 more
wiley   +1 more source