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Genetics and SUDEP: Challenges and Future Directions
Seizure: the Journal of the British Epilepsy Association, 2023Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related deaths in children and adults with epilepsy. The incidence of SUDEP in children and adults is equal, approximately 1.2 per 1000-person years. Although inroads have been made in our understanding of SUDEP, its pathophysiology remains unknown.
Robyn Whitney +2 more
exaly +3 more sources
SUDEP research: Challenges for the future
Epilepsy & Behavior, 2013Universidade Federal de Sao Paulo EPM UNIFESP, Disciplina Neurol Expt, Escola Paulista Med, Sao Paulo ...
Carla A, Scorza +2 more
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Neurology, 2019
Sudden unexpected death in epilepsy (SUDEP) has an incidence of 1–2 cases per 1,000 patients with epilepsy per year,1 and all of those caring for patients with epilepsy will encounter it at some point. There are many unknowns about SUDEP, and we do not talk about it with our patients, likely because of the lack of knowledge about the mechanism causing ...
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Sudden unexpected death in epilepsy (SUDEP) has an incidence of 1–2 cases per 1,000 patients with epilepsy per year,1 and all of those caring for patients with epilepsy will encounter it at some point. There are many unknowns about SUDEP, and we do not talk about it with our patients, likely because of the lack of knowledge about the mechanism causing ...
openaire +2 more sources
Postictal Central Apnea as a Cause of SUDEP: Evidence From Near‐SUDEP Incident
Epilepsia, 2000Summary: While undergoing video‐EEG monitoring, a 20‐year‐old woman had a 56‐second convulsive seizure, after which she developed persistent apnea. The rhythm of the electrocardiogram complexes was unimpaired for approximately 10 seconds, after which it gradually and progressively slowed until it stopped 57 seconds later.
E L, So, M C, Sam, T L, Lagerlund
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Epilepsy and Behavior, 2017
The North American SUDEP Registry (NASR) is a repository of clinical data and biospecimens in cases of sudden unexpected death in epilepsy (SUDEP), a leading cause of epilepsy-related deaths. We assessed whether bereaved families were aware of SUDEP before their family member's death and their preferences for SUDEP disclosure.
Laura Gould +2 more
exaly +3 more sources
The North American SUDEP Registry (NASR) is a repository of clinical data and biospecimens in cases of sudden unexpected death in epilepsy (SUDEP), a leading cause of epilepsy-related deaths. We assessed whether bereaved families were aware of SUDEP before their family member's death and their preferences for SUDEP disclosure.
Laura Gould +2 more
exaly +3 more sources
Pathology, 2014
Those dying suddenly on a background of a history of epilepsy (SUDEP) are seen frequently in the coronial setting. Issues around death certification will be discussed, along with the approach to the post-mortem examination, purported mechanisms of death in SUDEP and the emerging role of genetic studies in epilepsy related deaths.
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Those dying suddenly on a background of a history of epilepsy (SUDEP) are seen frequently in the coronial setting. Issues around death certification will be discussed, along with the approach to the post-mortem examination, purported mechanisms of death in SUDEP and the emerging role of genetic studies in epilepsy related deaths.
openaire +1 more source
Neurology, 2005
To examine the influence of various factors on the risk of sudden unexpected death in epilepsy (SUDEP).The authors investigated 154 cases in which a postmortem examination was performed. Each case had four controls with epilepsy from the community, matched for age and geographic location.
Y, Langan, L, Nashef, J W, Sander
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To examine the influence of various factors on the risk of sudden unexpected death in epilepsy (SUDEP).The authors investigated 154 cases in which a postmortem examination was performed. Each case had four controls with epilepsy from the community, matched for age and geographic location.
Y, Langan, L, Nashef, J W, Sander
openaire +2 more sources
Neurology, 2020
It was not that long ago that some believed there was little point in discussing sudden unexpected death in epilepsy (SUDEP) with patients. Why cause anxiety, it was argued, if the risk could not be influenced? The results of the landmark study by Sveinsson et al.1–3 reporting on a nationwide population-based case–control study of 255 SUDEP cases from ...
Lina, Nashef, Fergus, Rugg-Gunn
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It was not that long ago that some believed there was little point in discussing sudden unexpected death in epilepsy (SUDEP) with patients. Why cause anxiety, it was argued, if the risk could not be influenced? The results of the landmark study by Sveinsson et al.1–3 reporting on a nationwide population-based case–control study of 255 SUDEP cases from ...
Lina, Nashef, Fergus, Rugg-Gunn
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SUDEP—Pharmakologische Einflüsse
Zeitschrift für Epileptologie, 2006Das derzeitige Wissen uber medikamentose Einflusse auf die Inzidenz eines plotzlichen ungeklarten bzw. unerwarteten Todes bei Epilepsie (englisch: sudden unexplained/unexpected death in epilepsy patients; SUDEP) ist nicht schlussig. Obwohl Antiepileptika ebenso wie andere Medikamente wiederholt als moglicher Risikofaktor angeschuldigt wurden, lasst ...
Holger Schmidt, Günter Krämer
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Is the “unexpected” in SUDEP expectable?
IAR Journal of Medical Sciences, 2020We reviewed the article by [1] which presented a retrospective study of 220 patients with sudden unexpected death in epilepsy (SUDEP) from the North American SUDEP Registry (NASR), concluding that closer collaboration between death investigators and epilepsy communities is necessary to enhance the understanding of SUDEP. While the study is valuable, we
Finsterer J +3 more
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