Results 11 to 20 of about 3,023 (118)

Let’s talk SUDEP [PDF]

Archives of Neuropsychiatry, 2019
Sudden unexplained death in epilepsy (SUDEP) is a devastating complication of epilepsy which was under-recognized in the recent past despite its clear importance. In this review, we examine the definition of SUDEP, revise current pathophysiological theories, discuss risk factors and preventative measures, disclose tools for appraising the SUDEP risk ...
Ayşe Deniz, Elmali, Nerses, Bebek, Betül, Baykan   +2 more
openaire   +2 more sources

SUDEP in the North American SUDEP Registry [PDF]

Neurology, 2019
To obtain medical records, family interviews, and death-related reports of sudden unexpected death in epilepsy (SUDEP) cases to better understand SUDEP.All cases referred to the North American SUDEP Registry (NASR) between October 2011 and June 2018 were reviewed; cause of death was determined by consensus review. Available medical records, death scene
Verducci, Chloe, Hussain, Fizza, Donner, Elizabeth, Moseley, Brian D., Buchhalter, Jeffrey, Hesdorffer, Dale, Friedman, Daniel, Devinsky, Orrin   +7 more
openaire   +2 more sources

Project SUDEP-actie

Epilepsie, periodiek voor professionals, 2021
Het Netwerk Epilepsiezorg heeft in het project SUDEP-actie twee folders ontwikkeld over SUDEP, één voor patiënten en één voor professionals. Het doel van het project is meer bewustwording creëren over SUDEP en tegelijkertijd informatie beschikbaar stellen.
openaire   +2 more sources

Gaining perspective on SUDEP [PDF]

Neurology, 2017
Epilepsy is one of the most common neurologic disorders, affecting people of all ages and backgrounds. It is often burdensome, even when seizures are controlled: patients generally require daily costly medications with adverse effects and have higher rates of depression, anxiety, and cognitive disturbances.
Barbara A, Dworetzky, Jaideep, Kapur
openaire   +2 more sources

Cardiorespiratory cross‐frequency coupling biomarker for sudden unexpected death in epilepsy

Epilepsia, EarlyView.
Abstract Objective Sudden unexpected death in epilepsy (SUDEP) often follows generalized tonic–clonic seizures during sleep, likely resulting from impaired brainstem cardiorespiratory function. We used ictal electrocardiogram (ECG)‐based cross‐frequency phase–amplitude coupling (PAC) to detect cardiorespiratory disruptions, comparing SUDEP to non‐SUDEP
Adam C. Gravitis, Richard Wennberg, Peter L. Carlen, Yotin Chinvarun, Victor Lira, Juliana Laze, Orrin Devinsky, Berj L. Bardakjian   +7 more
wiley   +1 more source

SUDEP, the aftermath: supporting the bereaved [PDF]

Practical Neurology, 2017
Sudden unexpected death in epilepsy is a recurring calamity, yet there is little evidence to guide standards of care for supporting the bereaved. Grief in bereavement includes loss, feelings of guilt, anger and blame. There is also the shock and trauma of the sudden event. How can this be alleviated?
Nashef, Lina, Leach, John Paul
openaire   +2 more sources

Synchrotron‐generated microbeams as a radiosurgical alternative for drug‐resistant epilepsies: Proof of concept in a mouse model of mesiotemporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective One‐third of patients with epilepsy, particularly those with mesial temporal lobe epilepsy (MTLE), remain resistant to medication. Resective surgery, the gold standard, is highly invasive and carries significant risks. Here, using a mouse model, we explored the potential of microbeam radiation therapy (MRT), a new technique based on ...
Loan Samalens, Camille Beets, Clothilde Courivaud, Sarvenaz Keshmiri, Jean‐François Adam, Paolo Pellicioli, Emmanuel Luc Barbier, Raphaël Serduc, Antoine Depaulis   +8 more
wiley   +1 more source

L‐Relationship between uncertainty and average seizure frequency in clinical trials of antiseizure medications

Epilepsia, EarlyView.
Abstract Objective Antiseizure medications are approved based on clinical trials that demonstrate their efficacy as measured by reductions in seizure frequency (SF). When designing these trials, trialists must select inclusion criteria where SF can be reliably measured to maintain statistical power.
Wesley T. Kerr, Neo Kok, Katherine N. McFarlane, Advith S. Reddy, Lavanya Biju, Jacqueline A. French, Daniel M. Goldenholz   +6 more
wiley   +1 more source

Cardiac-specific Kv1.1 deficiency alters cardiomyocyte electrophysiology without modifying overall cardiac function or arrhythmia susceptibility. [PDF]

Exp Physiol
Abstract The leading cause of epilepsy‐related mortality is sudden unexpected death in epilepsy (SUDEP), resulting from seizure‐induced cardiorespiratory arrest by mechanisms that remain unresolved. Mutations in ion channel genes expressed in both brain and heart represent SUDEP risk factors because they can disrupt neural and cardiac rhythms ...
Halvorson K, Si M, Trosclair K, Aughenbaugh E, Parkinson M, Gautier-Hall NM, Watts M, Kizek F, Bhuiyan MS, Dominic P, Hamilton KA, Glasscock E.   +11 more
europepmc   +2 more sources

Prospective evaluation of a seizure detection wearable device for timely interventions in an epilepsy monitoring unit

Epilepsia, EarlyView.
Abstract Objective This study aimed to evaluate the real‐world performance of a wrist‐worn seizure detection device for timely clinical interventions within an epilepsy monitoring unit (EMU). Methods We conducted a prospective observational study involving patients admitted to the EMU at a tertiary care center.
Amirhossein Jahani, Daniel Alejandro Galindo Lazo, Isabel Sarzo Wabi, Oumayma Gharbi, Manon Robert, Juan Pablo Millan, Gianluca D'onofrio, Alexis Robin, Dang K. Nguyen, Elie Bou Assi   +9 more
wiley   +1 more source