Results 81 to 90 of about 5,831 (244)

Dead in the Night: Sleep-Wake and Time-Of-Day Influences on Sudden Unexpected Death in Epilepsy

Frontiers in Neurology, 2018
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related death in patients with refractory epilepsy. Convergent lines of evidence suggest that SUDEP occurs due to seizure induced perturbation of respiratory, cardiac, and ...
Benton S. Purnell, Benton S. Purnell, Benton S. Purnell, Roland D. Thijs, Roland D. Thijs, Roland D. Thijs, Gordon F. Buchanan, Gordon F. Buchanan, Gordon F. Buchanan   +8 more
doaj   +1 more source

SUDEP and heart rate variability [PDF]

Epilepsy Research, 2010
We read with interest the important article by Surges et al. regarding their case-controlled study of heart rate variability (HRV) and sudden unexplained death in epilepsy (SUDEP) (Surges et al 2009). Surges retrospectively examined multiple measures of HRV in a group of seven SUDEP victims and seven age-matched controls.
Christopher M. DeGiorgio, Andrew C. DeGiorgio   +1 more
openaire   +2 more sources

Deep learning–based detection of generalized convulsive seizures using a wrist‐worn accelerometer

Epilepsia, EarlyView.
Abstract Objective To develop and validate a wrist‐worn accelerometer‐based, deep‐learning tunable algorithm for the automated detection of generalized or bilateral convulsive seizures (CSs) to be integrated with off‐the‐shelf smartwatches. Methods We conducted a prospective multi‐center study across eight European epilepsy monitoring units, collecting
Antoine Spahr, Adriano Bernini, Pauline Ducouret, Christoph Baumgartner, Johannes P. Koren, Lukas Imbach, Sàndor Beniczky, Sidsel A. Larsen, Sylvain Rheims, Martin Fabricius, Margitta Seeck, Berhard J. Steinhoff, Isabelle Beuchat, Jonathan Dan, David A. Atienza, Charles‐Edouard Bardyn, Philippe Ryvlin   +16 more
wiley   +1 more source

Two‐year outcomes of epicranial focal cortex stimulation in pharmacoresistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to report on the long‐term safety and efficacy of epicranial focal cortex stimulation (FCS) using the EASEE device as adjunctive neuromodulatory therapy in improving seizure control in adults with pharmacoresistant epilepsy originating from one predominant epileptogenic zone.
Andreas Schulze‐Bonhage, Martin Hirsch, Susanne Knake, Ann Mertens, Michael Rademacher, Elisabeth Kaufmann, Josua Kegele, Carolin Jenkner, Volker Coenen, Martin Glaser, Sergiu Groppa, Yaroslav Winter, for the EASEE Study Group   +12 more
wiley   +1 more source

Incidence of sudden unexpected death in epilepsy in New Zealand: A prospective population‐wide, 2‐year study

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to determine the incidence of sudden unexpected death in epilepsy (SUDEP) in New Zealand. Methods We attempted to prospectively identify all people with epilepsy (PWE) in New Zealand who died from SUDEP after August 1, 2019.
Peter S. Bergin, Sunayana Sasikumar, Erica Beilharz, Charley Glenn, Robert Scragg   +4 more
wiley   +1 more source

Are Variants Causing Cardiac Arrhythmia Risk Factors in Sudden Unexpected Death in Epilepsy?

Frontiers in Neurology, 2020
Sudden unexpected death in epilepsy (SUDEP) is the most common cause of premature mortality in individuals with epilepsy. Acute and adaptive changes in heart rhythm in epilepsy implicate cardiac dysfunction as a potential pathogenic mechanism in SUDEP ...
Lauren E. Bleakley, Ming S. Soh, Richard D. Bagnall, Richard D. Bagnall, Lynette G. Sadleir, Samuel Gooley, Christopher Semsarian, Christopher Semsarian, Ingrid E. Scheffer, Ingrid E. Scheffer, Ingrid E. Scheffer, Samuel F. Berkovic, Christopher A. Reid   +12 more
doaj   +1 more source

Time to prerandomization seizure count design sufficiently assessed the safety and tolerability of perampanel for the treatment of focal seizures

Epilepsia, EarlyView.
Abstract Objective In traditionally designed randomized clinical trials of antiseizure medications, participants take a blinded treatment for a prespecified number of weeks, irrespective of continued seizures. The alternative design time to prerandomization monthly seizure count (T‐PSC) allows participants to end the blinded treatment after an ...
Wesley T. Kerr, Leock Y. Ngo, Liang Zhu, Anna Patten, Jocelyn Y. Cheng, Lavanya Biju, Jacqueline A. French   +6 more
wiley   +1 more source

Intersection of epilepsy and cardiac health: Insights from electrocardiography and syndromic associations

Epilepsia, EarlyView.
Abstract Epilepsy is a chronic neurological condition marked by recurrent, uncontrolled seizures. Identifying comorbidities in epilepsy is critical for preventing mortality. Among these, the autonomic nervous system's role in epilepsy often manifests as cardiac disorders. Patients with epilepsy (PWE), particularly those with poorly controlled seizures,
Enes Akyuz, Feyza Sule Aslan, Tugba Eyigurbuz   +2 more
wiley   +1 more source

Development of a preclinical testing platform for clinically relevant therapy for Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Patients with drug‐resistant epilepsy, including Dravet syndrome, are frequently prescribed multiple antiseizure medications. Nevertheless, people with Dravet syndrome often have inadequate seizure control, and there is an ongoing unmet clinical need to identify novel therapeutics.
Jeffrey A. Mensah, Kyle E. Thomson, Jennifer L. Huff, Tia Freeman, Christopher A. Reilly, Joseph E. Rower, Cameron S. Metcalf, Karen S. Wilcox   +7 more
wiley   +1 more source

Sex‐specific differences in mortality and neurocardiac interactions in the Kv1.1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP)

The Journal of Physiology, EarlyView.
Abstract figure legend The Kcna1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP) exhibits sex‐specific differences in SUDEP risk. Female mice exhibit a lower SUDEP risk than males, despite similar seizure characteristics and interictal cardiac function across sexes.
Kelsey Paulhus, Praveen Kumar, Kelly Kneale, T. Noah Hutson, Nicole M. Gautier‐Hall, Deng‐Shan Shiau, Megan Watts, Krystle Trosclair, Hemangini A. Dhaibar, Paari Dominic, Leonidas Iasemidis, Edward Glasscock   +11 more
wiley   +1 more source