Results 101 to 110 of about 2,426,055 (315)
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Like a Fly against a Pane of Glass: Simone Weil in the Context of Contemporary Theories of Suffering
Labyrinth: An International Journal for Philosophy, Value Theory and Sociocultural Hermeneutics, 2023 The last five years have seen a welcome rise in philosophical research on suffering. In this paper I will introduce the main new proposals and point out their respective weak-nesses.
Eva-Maria Düringer
doaj
On the media construction of international disasters [PDF]
, 2014 For most people living in western countries, disasters are a priori cases of distant suffering as they mainly affect cultural or ethnic others. News media thus play a pivotal role in giving publicity and meaning to the numerous instances of global ...
Joye, Stijn
core
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Palliative Care Academic Career Awards: A Public-Private Partnership to Improve Care for the Most Vulnerable [PDF]
, 2003 Palliative care, an increasingly important medical field that focuses on the relief of pain and suffering, is in danger of not being able to meet the needs of America's aging population, or anyone of any age suffering from serious or life-threatening ...
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
The Mask of the Warrior: unraveling deep-seated health vulnerabilities in veteran identities
Frontiers in SociologyAs service members transition from deployment to civilian life, they are also expected to reintegrate into society. An important part of this process is to “soften up” veteran or warrior identities and open up the self for both existing and new ...
Jan Grimell
doaj +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source