Results 121 to 130 of about 65,550 (268)

Owing Me, Owing You: Sufficiency, Demandingness, and Global Justice

open access: yesLaw, Ethics and Philosophy, 2018
SIBA HARB, DAVID V. AXELSEN
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Why not More Equality? Sufficientarianism and Inequalities above the Threshold

open access: yesLaw, Ethics and Philosophy, 2018
PIERRE-ÉTIENNE VANDAMME
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Maternal-neonatal vitamin D gradient at birth in Ilorin, Nigeria: a comparative cross-sectional study. [PDF]

open access: yesMatern Health Neonatol Perinatol
Ayodeji O   +12 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Execution Sufficiency and State Sufficiency: Record Sufficiency in Reflexive Research Systems

open access: yes
Keywordsreflexive research systemsrecord sufficiencyexecution sufficiencystate sufficiencyreplayabilityresumabilityAI-mediated research Access rightOpen Access LicenseCC BY 4.0(only use this if that is your intended license) DOI fields Concept DOI10.5281/zenodo.18902418 Version DOI10.5281/zenodo.19042930 Recommended “Related identifiers” entry ...
openaire   +2 more sources

Organic acids counteract the determinate root development induced by phosphate deprivation in <i>Arabidopsis thaliana</i>. [PDF]

open access: yesPlant Signal Behav
Corona-Sánchez I   +6 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

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