Results 51 to 60 of about 7,199 (168)

Challenges and Possibilities of Shifting to Marketing Compatible with a Sufficiency Approach:

Maketingu Janaru
Despite most large corporations engaging with Sustainable Development Goals, sustainability issues show no signs of improvement. The limitations of the efficiency approach, which forms the basis of conventional environmental policies, have been ...
Yasuhiro Haga
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Sufficiency, consumption patterns and limits: a survey of French households

Buildings & Cities
How can the concept of consumption corridors be operationalised? This research provides socio-demographic knowledge of the setting of the upper limit. Four distinct ‘modes of consumption’ are identified, based on material consumption levels and openness ...
Jérémy Bouillet, Catherine Grandclément   +1 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Will decarbonising buildings be enough? Constrain and redistribute growth in floor area

Agathón
While decarbonising the built environment is a dominant strategy in tackling climate change, centred on renewable energies and energy efficiency, it overlooks the role played by growth in built floor area in overconsumption of material and other natural
David Ness
doaj   +1 more source

Pediatric cardiologists’ sufficiency and their activities in Russian Federation, 2013-2017

Российский кардиологический журнал, 2019
The staffing of medical specialists plays an important role in the timely provision of specialized medical care to the population.Aim. To analyze the sufficiency of pediatric cardiologists and their activities in the Russian Federation.Material and ...
I. M. Son, M. A. Ivanova, T. A. Sokolovskaya, D. V. Vankov, E. V. Ogrizko, E. V. Zimina   +5 more
doaj   +1 more source