Results 71 to 80 of about 7,199 (168)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Reducing demand: a quantitative analysis of energy service demand indicators in sufficiency-oriented scenarios

Environmental Research Communications
A reduction of energy service demand in all sectors is required to reach ambitious climate and other sustainability goals. A growing number of energy and climate scenarios does include detailed assumptions and quantified parameters for the reduction of ...
Frauke Wiese, Carina Zell-Ziegler, Celia Burghardt, Yannick Kloos, Mirko Schäfer   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Flight quotas outperform focused mitigation strategies in reducing the carbon footprint of academic travel

Environmental Research Letters
The carbon footprint of academia has become a prominent concern and a burgeoning research area, with a notable focus on greenhouse gas emissions (GHG) from research-related travels.
Tamara Ben-Ari, Gaëlle Lefort, Jérome Mariette, Olivier Aumont, Laurent Jeanneau, Alexandre Santerne, Aymeric Spiga, Philippe-e Roche   +7 more
doaj   +1 more source

Living smaller: acceptance, effects and structural factors in the EU

Buildings & Cities
This article examines limits to per capita living space (i.e. living smaller and/or sharing living space) as a measure for achieving sufficiency in housing.
Matthias Lehner, Jessika Luth Richter, Halliki Kreinin, Pia Mamut, Edina Vadovics, Josefine Henman, Oksana Mont, Doris Fuchs   +7 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Energy sufficiency and recognition justice: a study of household consumption

Buildings & Cities
The energy ‘crisis’ in Switzerland during the winter of 2022–23 highlighted the need to integrate the idea of sufficiency into previously efficiency-focused discourses and policies.
Alice Guilbert
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Acceptability of sufficiency consumption policies by Finnish households

Buildings & Cities
Sufficiency policies aim to decrease and avoid the demand for energy, materials, land and water. This research examines the acceptability of sufficiency consumption policies among Finnish households and how Finnish households experience sufficiency as a ...
Essi Nuorivaara, Sanna Ahvenharju
doaj   +1 more source