Results 51 to 60 of about 244,425 (248)

Some descent Dai-Liao-type conjugate gradient methods for vector optimization

Franklin Open
Conjugate gradient methods play a crucial role in solving unconstrained optimization problems and have recently been extended to vector optimization problems (VOPs).
Jamilu Yahaya, Poom Kumam, Abdulmalik Usman Bello   +2 more
doaj   +1 more source

Stochastic Optimization from Distributed, Streaming Data in Rate-limited Networks

, 2018
Motivated by machine learning applications in networks of sensors, internet-of-things (IoT) devices, and autonomous agents, we propose techniques for distributed stochastic convex learning from high-rate data streams.
Bajwa, Waheed U., Nokleby, Matthew
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Global Convergence of a Spectral Conjugate Gradient Method for Unconstrained Optimization

Abstract and Applied Analysis, 2012
A new nonlinear spectral conjugate descent method for solving unconstrained optimization problems is proposed on the basis of the CD method and the spectral conjugate gradient method.
Jinkui Liu, Youyi Jiang
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A THREE-TERM CONJUGATE GRADIENT METHOD FOR LARGE-SCALE MINIMIZATION IN ARTIFICIAL NEURAL NETWORKS

Barekeng
Conjugate Gradient (CG) methods are widely used for solving unconstrained optimization problems due to their efficiency and low memory requirements. However, standard CG methods may not always guarantee sufficient descent condition, which can impact ...
Umar A Omesa, Muhammad Y. Waziri, Issam A. R. Moghrabi, Sulaiman M. Ibrahim, Gudu E B, Fakai S L, Rabiu Bashir Yunus, Elissa Nadia Madi   +7 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A new three-term conjugate gradient-based projection method for solving large-scale nonlinear monotone equations

Mathematical Modelling and Analysis, 2019
A new three-term conjugate gradient-based projection method is presented in this paper for solving large-scale nonlinear monotone equations. This method is derivative-free and it is suitable for solving large-scale nonlinear monotone equations due to its
Mompati Koorapetse, Professor Kaelo
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source