Results 101 to 110 of about 5,211,856 (273)

An Adaptive Domain Partitioning Technique for Meshfree-Type Methods

open access: yesJournal of Applied Mathematics, 2012
An overlapping domain partitioning based on adapting nodes is presented for the meshless-type methods. The decomposition of the domain is carried out based on the distribution of the nodes produced rather than the geometry of the problem.
Kamal Shanazari
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Dimension Reduction in Nonparametric Discriminant Analysis [PDF]

open access: yes
A dimension reduction method in kernel discriminant analysis is presented, based on the concept of dimension reduction subspace. Examples of application are discussed.
Santiago Velilla, Adolfo Hernández
core  

Series expansion for functional sufficient dimension reduction

open access: yesJournal of Multivariate Analysis, 2014
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Heng Lian, Gaorong Li
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Variable Selection in sparse Sufficient Dimension Reduction (SDR) models.

open access: yes, 2022
How to select variables in high-dimensional regression models using sufficient dimension reduction and regularized ...
Withanage, Yeshan
core   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Pseudo likelihood and dimension reduction for data with nonignorable nonresponse

open access: yesStatistical Theory and Related Fields, 2018
Tang et al. (2003. Analysis of multivariate missing data with nonignorable nonresponse. Biometrika, 90(4), 747–764) and Zhao & Shao (2015. Semiparametric pseudo-likelihoods in generalized linear models with nonignorable missing data.
Ji Chen, Bingying Xie, Jun Shao
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

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