Results 241 to 250 of about 9,133 (278)
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Sugammadex in anesthesia practice
Expert Opinion on Pharmacotherapy, 2010Neuromuscular blocking agents are currently used during anesthesia but put patients at risk of postoperative paralysis. If the residual neuromuscular blockade is not reversed properly at the end of anesthesia, there is a risk of hypoxemia and pulmonary complication. Sugammadex is able to fully reverse different degrees of neuromuscular blockade induced
Benoit Plaud, Philippe Duvaldestin
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Revista Española de Anestesiología y Reanimación, 2014
Sugammadex is the first selective relaxant binding agent. It allows rapid reversal of any degree of neuromuscular blockade induced by steroidal neuromuscular blocking agents. Sugammadex acts by encapsulation of the neuromuscular blocking agent. This prevents the drug from acting on prejunctional and postjunctional nicotinic receptors, allowing ...
Epemolu, O., Bom, A.
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Sugammadex is the first selective relaxant binding agent. It allows rapid reversal of any degree of neuromuscular blockade induced by steroidal neuromuscular blocking agents. Sugammadex acts by encapsulation of the neuromuscular blocking agent. This prevents the drug from acting on prejunctional and postjunctional nicotinic receptors, allowing ...
Epemolu, O., Bom, A.
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Preclinical pharmacology of sugammadex
Journal of Critical Care, 2009Since the introduction of nondepolarizing neuromuscular blocking agents, acetylcholinesterase inhibitors have been used to increase the speed of recovery from neuromuscular blockade. The major disadvantages of acetylcholinesterase inhibitors are their lack of activity against profound neuromuscular blockade and their activity outside the neuromuscular ...
Anton Bom +3 more
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Sugammadex and oral contraceptives
Current Opinion in AnaesthesiologyPurpose of review This review article explores the evidence regarding sugammadex (MSD Australia) and its potential interaction with hormonal contraceptives. The impact of recent clinical trials and review articles is examined.
Devoy, Tamblyn, Smith, Natalie
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Incidence of hypersensitivity and anaphylaxis with sugammadex
Journal of Clinical Anesthesia, 2018To evaluate the incidence of hypersensitivity and anaphylaxis after administration of sugammadex.Retrospective analysis.Sugammadex clinical development program and post-marketing experience.Surgical patients and healthy volunteers who received sugammadex or placebo/comparator with anesthesia and/or neuromuscular blockade (NMB).Sugammadex administered ...
Tiffany Woo +7 more
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Annales Françaises d'Anesthésie et de Réanimation, 2009
Sugammadex is a new molecule derived from a known pharmacological class : the cyclodextrins known and used in human for many years. It was recently demonstrated that cyclodextrins could encapsulate and bind strongly steroidal neuromuscular blocking agents. Among cyclodextrins gamma-cyclodextrins proved to be more efficient. The binding of cyclodextrins
C. Meistelman, T. Fuchs-Buder
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Sugammadex is a new molecule derived from a known pharmacological class : the cyclodextrins known and used in human for many years. It was recently demonstrated that cyclodextrins could encapsulate and bind strongly steroidal neuromuscular blocking agents. Among cyclodextrins gamma-cyclodextrins proved to be more efficient. The binding of cyclodextrins
C. Meistelman, T. Fuchs-Buder
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Sugammadex-Associated Bronchospasm
American Journal of Therapeutics, 2021Kovid Trivedi +2 more
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Sugammadex and labetalol precipitation
Journal of Clinical Anesthesia, 2020Jeffrey D. White +3 more
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