Results 51 to 60 of about 1,920,357 (308)

Discrete Adjoint-Based Simultaneous Analysis and Design Approach for Conceptual Aerodynamic Optimization [PDF]

INCAS Bulletin, 2017
In this paper, a simultaneous analysis and design method is derived and applied for a non-linear constrained aerodynamic optimization problem. The method is based on the approach of defining a Lagrange functional based on the objective function and the ...
Oliviu SUGAR-GABOR
doaj   +1 more source

Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. [PDF]

, 2018
Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport sugars across the plasma membrane. Due to their role in renal sugar reabsorption, SGLTs are targets for the treatment of type 2 diabetes.
Althoff, Thorsten, Bisignano, Paola, Friemann, Rosmarie, Ghezzi, Chiara, Grabe, Michael, Jacobson, Matthew P, Jo, Hyunil, Kalyanaraman, Chakrapani, Polizzi, Nicholas F, Wright, Ernest M   +9 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Impact of Smut (Sporisorium scitamineum) on Sugarcane's Above-Ground Growth and the Determinants of the Disease Intensity in the Ethiopian Sugarcane Plantations [PDF]

Research in Plant Disease
The development of sustainable smut management techniques requires an understanding of the impacts of smut on sugarcane growth and the relationships between smut intensity and meteorological variables, varieties, and crop types.
Samuel Tegene, Habtamu Terefe, Esayas Tena   +2 more
doaj   +1 more source

Molecular Detection of Pentastiridius leporinus, the Main Vector of the Syndrome ‘Basses Richesses’ in Sugar Beet

Insects, 2022
Monitoring of Pentastiridius leporinus (Hemiptera: Auchenorrhyncha: Cixiidae), representing the main vector of the syndrome ‘basses richesses’ (SBR) disease in sugar beet is based on morphological identification.
René Pfitzer, Mark Varrelmann, Georgia Hesse, Omid Eini   +3 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Genetic control over characteristic of 1000 seeds weight in hybrids of sugar beet and combining ability of crossbreeding components

Plant Varieties Studying and Protection, 2012
The article shows experimental data of interline hybrids of sugar beet on the basis of weight of 1000 seeds, genetic determination of characteristic based on the method of Hayman and topcrossed polytested crossbreeding is established, their comparison is
М. О. Корнєєва, О. В. Ненька, М. М. Ненька   +2 more
doaj   +1 more source

Manipulation of carbohydrate diet and ensuing changes in weight and glycogen storage in bumble bee (Bombus impatiens) queens [PDF]

, 2014
Bumble bees serve as important pollinators for human crops, but many of their populations have declined over the past 60 years. Bumble bee population decline is very important for humans because it reduces pollination services, which can lead to lower ...
Doan, Amy HoangAnh
core  

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source