Results 51 to 60 of about 920,137 (305)

Effects of circadian clock and light on melatonin concentration in Hypericum perforatum L. (St. John’s Wort)

Botanical Studies, 2020
Background Melatonin acts as a signaling hormone and entraining agent in many organisms. We studied the spatiotemporal regulation and influence of light (photoperiods, intensities, and spectral qualities) on melatonin concentration in the medicinal herb ...
Ming-Hsiu Chung, Tzu-Shing Deng
doaj   +1 more source

Sugar Store, Homebush Mill

, 2023
Album 3636: Queensland - transportation of cane over the Herbert River at the Macknade millMacknade River bridge and outer buildingsHomebush mill and Johnstone River bridgegeneral surroundings at Macknade and the equipment used at the ...
Photographer: Unknown, Colonial Sugar Refining Company Limited (1855 -)   +1 more
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Nonlinear Lifting-Line Model using a Vector Formulation of the Unsteady Kutta-Joukowski Theorem [PDF]

INCAS Bulletin, 2019
In this paper, a vector form of the unsteady Kutta-Joukowski theorem is derived and then used in the formulation of a general Lifting-Line Model capable of analysing a wide range of engineering problems of interest.
Oliviu SUGAR GABOR
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Discrete Adjoint-Based Simultaneous Analysis and Design Approach for Conceptual Aerodynamic Optimization [PDF]

INCAS Bulletin, 2017
In this paper, a simultaneous analysis and design method is derived and applied for a non-linear constrained aerodynamic optimization problem. The method is based on the approach of defining a Lagrange functional based on the objective function and the ...
Oliviu SUGAR-GABOR
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Governance risks of AI reasoning in urban infrastructure through Delphi audit of human and large language model judgment

Discover Cities
Cities are increasingly considering large language models (LLMs) to support smart city operations and infrastructure decision-making. While these tools promise efficiency, their use in public institutions raises concerns about accountability, reliability,
Alence Poudel, Carla Barrios, Paola De La Torre, Huy Ton, Trevor Surface, Varenya Mehta, Samanata Silwal   +6 more
doaj   +1 more source

EFFECT OF INOCULUM LEVEL, TYPE, PLANT AGE AND ASSESSMENT DATE ON EVALUATING SUGAR BEET RESISTANCE METHODS FOR ROOT-KNOT NEMATODE, Meloidogyne incognita [PDF]

Journal of Plant Protection and Pathology, 2009
The objectives of this study were to determine the effect of inoculum level, inoculation date, assessment date and inoculum type, on evaluating M. incognita resistance in sugar beet, and to optimize the resistance screening technique used to categorize ...
M. Maareg, I. Gohar,
doaj   +1 more source