Results 61 to 70 of about 2,702,288 (282)

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Sugar Transport in Conducting Elements of Sugar Beet Leaves [PDF]

Plant Physiology, 1969
Autoradiography was used to determine the distribution of labeled sugar in conducting elements of the blade and petiole of sugar beet leaves at intervals ranging from 5 sec to 24 hr. The processes of assimilation by the green cells, collection of sugar in the minor veins and export in phloem elements were demonstrated visually. It appears that in minor
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Gene Editing for Sugar Perception Transport and Source–Sink Optimization in Soybean

Agronomy
Sugars serve as primary energy sources and key essential signaling molecules, playing pivotal roles in regulating plant growth and development. Crop yield is tightly linked to the efficient partitioning of photoassimilates from source leaves to sink ...
Shuqi Ding, Li Chen, Wensheng Hou, Yupeng Cai   +3 more
doaj   +1 more source

Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: Evidence for broad based applications

iScience, 2021
Summary: Bacillus Calmette-Guerin (BCG) vaccinations improve glycemic control in juvenile-onset Type I diabetes (T1D), an effect driven by restored sugar transport through aerobic glycolysis.
Gabriella F. Shpilsky, Hiroyuki Takahashi, Anna Aristarkhova, Michele Weil, Nathan Ng, Kacie J. Nelson, Amanda Lee, Hui Zheng, Willem M. Kühtreiber, Denise L. Faustman   +9 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Sugar rush: Structural breakdown of plant sugar transport

Current Opinion in Structural Biology
Sugar transporters are essential for the long-distance carbon allocation in plants and contribute to both biotic and abiotic stress responses yet the molecular mechanisms of substrate specificity and conformational cycling are only beginning to emerge.
Kasper Andreasen Clowes, Camilla Gottlieb Andersen, Adriana Chrenková, Bjørn Panyella Pedersen   +3 more
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Sugar Transport in Neurospora crassa

Journal of Biological Chemistry, 1970
Abstract The transport of several sugars by cells of Neurospora crassa grown in shake culture has been investigated. 3-O-Methyl-d-glucose is a substrate for the glucose transport system in glucose-grown cells but cannot be phosphorylated by the ATP-dependent hexokinase which readily catalyzes the phosphorylation of d-glucose.
openaire   +2 more sources