Results 71 to 80 of about 115,506 (309)
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Alcohol consumption as a risk factor for suicidal behavior: A systematic review of associations at the individual and at the population level [PDF]
, 2016 -To provide an updated review of the magnitude of the relationship between alcohol use and suicidal behaviour at the individual and the population level.
Norstrøm, Thor-Arvid, Rossow, Ingeborg
core +3 more sources
Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
Suicidal altruism under random assortment [PDF]
, 2008 Questions: Can there be a selective explanation for suicide? Or are all suicides evolutionary mistakes, ever pruned by natural selection to the extent that the tendency to perform them is heritable?
Cabrales, Antonio, Pollock, Gregory B.
core +1 more source
Risks and opportunities in adolescence: Understanding adolescent mental health difficulties [PDF]
, 2009 Widespread concerns about adolescent mental health difficulties have generated intense debate and resulted in adolescence being high on the policy agenda.
Briggs, Stephen
core +1 more source
Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion
Advanced Science, EarlyView.The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li +10 more
wiley +1 more source
Suicidal behaviour and suicide prevention in later life [PDF]
Maturitas, 2014 Despite a general decline in late life suicide rates over the last 30 years, older people have the highest rates of suicide in most countries. In contrast, non-fatal suicidal behaviour declines with age and more closely resembles suicide than in younger age groups.
openaire +3 more sources
Distinct Biotypes of Visual Perception in Major Depressive Disorder
Advanced Science, EarlyView.In a discover dataset (272 acute MDD patients), this work identifies a novel depression biotype characterized by impaired visual motion perception, using machine learning clustering. An independent dataset confirms the robustness of this biotype through cross‐validation and demonstrates its generalizability.
Zhuoran Cai +13 more
wiley +1 more source
Journal of Global Health Reports, 2019 # Background A significant proportion of persons who were contemplating suicide or completed suicide had met with a health care provider in the preceding months, however suicidal behaviour was not detected.
Joseph Muwonge +3 more
doaj +1 more source
Suicidal behaviour in postnatal mothers in northwestern Ethiopia: a cross-sectional study
BMJ Open, 2019 Aim To assess the prevalence and associated factors of suicidal behaviour (suicidal ideation, plan or suicide attempt) in postpartum mothers.Method An institutional cross-sectional study was employed from March to April 2017.Setting Two primary health ...
Habte Belete, Eyaya Misgan
doaj +1 more source