Results 61 to 70 of about 30,495 (308)

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Electroencephalographic risk markers of suicidal behaviour

, 2016
Since its inception nearly 100 years ago, EEG (electroencephalography) has offered a non-invasive approach to recording the intrinsic electrical activity of the brain.
Kaschka, Wolfgang P., Steyer, Jürgen, J�rgen Steyer, Martin Jandl, Hodgkinson, Steve, Jandl, Martin, Wolfgang P. Kaschka, Steve Hodgkinson   +7 more
core   +1 more source

Genetic Code Expanded T Cell for Controllable Immunotherapy

Advanced Science, EarlyView.
Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang, Yingao Gao, Yeyu Su, Yong Wang, Tao Liu   +4 more
wiley   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

The prevalence of suicidal behaviour and associated risk factors in grade 8 learners in Durban

South African Family Practice, 2014
Objectives: Most of the research on suicidal behaviour in youth focuses on developed countries. Less is known about the prevalence of suicidal behaviour and associated risk factors in community samples of youth who do not present for mental health care ...
N. Vawda
doaj   +1 more source

The psychosocial toll of Dublin III on asylum seekers in the Netherlands

American Journal of Community Psychology, EarlyView.
Abstract The Dublin III Regulation determines which EU Member State is responsible for examining asylum claims, but its implementation carries significant consequences for those subjected to it. This study examines how Dublin III, as implemented in the Netherlands, affects asylum seekers' psychosocial wellbeing using Silove′s Adaptation and Development
Imen El Amouri
wiley   +1 more source

Risk factors for suicidal behaviour in late-life depression: A systematic review

, 2022
BACKGROUND Suicide is a leading cause of preventable death worldwide, with its peak of maximum incidence in later life. Depression often puts an individual at higher risk for suicidal behaviour.
Diaz-Carracedo, Patricia, Hervas, Gonzalo, Rico-Uribe, Laura Alejandra, Fernandez-Rodrigues, Veronica, Diaz-Marsa, Marina, Sánchez Carro, Yolanda, De La-Torre Luque, Alejandro Francisco, Pemau, Andres, de la Torre-Luque, Alejandro, Díaz Carracedo, Patricia, Lagunas García, Luisa Natalia, Pemau Gurumeta, Andrés, Lagunas, Luisa Natalia, Díaz Marsa, Marina Francisca, Hervás Torres, Gonzalo, Sanchez-Carro, Yolanda, Rico Uribe, Laura Alejandra, Fernandez Rodrigues, Veronica   +17 more
core   +1 more source

Using photovoice to understand community perceptions of firearm risks and protective factors among Asian Americans

American Journal of Community Psychology, EarlyView.
Abstract This study used photovoice methodology to explore Asian Americans' perspectives on the root causes and protective factors of firearm violence in their communities. Photovoice provided a participatory platform for community members to document lived experiences and identify priorities for change.
Tsu‐Yin Wu, Szu‐Hsien Chen, Xining Yang, Ken Resnicow, Hsing‐Fang Hsieh   +4 more
wiley   +1 more source

Testing the Integrated Motivational-Volitional Model of suicidal behavior in a young Danish population

BMC Psychiatry
Introduction The Integrated Motivational-Volitional model for suicidal behaviour (IMV-model) is a predominant model of suicide risk which was developed to enhance understanding of the emergence of suicidal thoughts and the transition from suicidal ...
Erik Christiansen, Agnieszka Konieczna, Christina Petrea Larsen, Sarah Grube Jakobsen, Rory C. O´Connor   +4 more
doaj   +1 more source

Suicidal behaviour and suicide prevention in later life [PDF]

Maturitas, 2014
Despite a general decline in late life suicide rates over the last 30 years, older people have the highest rates of suicide in most countries. In contrast, non-fatal suicidal behaviour declines with age and more closely resembles suicide than in younger age groups.
openaire   +3 more sources