Results 81 to 90 of about 177,236 (307)

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

Associations of overactive bladder (OAB) with suicidal ideation incidence and all-cause mortality among the U.S. population

BMC Psychiatry
Background Few studies have explored the correlation between overactive bladder (OAB) and suicidal ideation. This study aims to investigate the association between OAB and suicidal ideation, as well as the relationship between OAB and all-cause mortality
Hongyang Gong, Shaoqun Huang
doaj   +1 more source

Suicidal Ideation and Self-injury Prevalence and Impairment in an Urban Integrated Primary Care Clinic [PDF]

, 2020
Introduction: Suicide is the second leading cause of death for adolescents (Rosenbaum & Ougrin, 2019). Pediatric primary care staff are often the first line of intervention for youth presenting with suicidal thoughts and NSSI (Taliaferro et al., 2013 ...
Behrhorst, Kathryn L., Jones, Ph.D., Heather A., Rybarczyk, Ph.D., Bruce   +2 more
core   +1 more source

Suicidal ideation and suicide attempts among asthma [PDF]

Annals of General Psychiatry, 2016
The present study aimed to investigate the mental health status in patients with asthma and assess the effects of asthma on suicidal ideation and attempts using a representative sample from Korea.Individual-level data were obtained from 228,744 participants (6372 with asthma and 222,372 without asthma) of the 2013 Korean Community Health Survey ...
Chung, Jae Ho, Kim, Sun- Hyun, Lee, Yong Won   +2 more
openaire   +2 more sources

Occurrence and Correlates of Suicidal Thoughts Among Young Autistic Users of a Mental Health App

Autism Research, EarlyView.
ABSTRACT Young autistic people experience disproportionately high rates of mental health challenges, yet little is known about factors associated with suicidality in this group. This study leveraged anonymous self‐report data to identify correlates of suicidal thoughts among 365 young users (aged approximately 11–25 years) of a mental health app in the
T. L. Procyshyn, E. M. Weir, M. Pelton, T. Chikaura, H. Hodges, K. Comley, S. Godson, C. Allison, S. Baron‐Cohen   +8 more
wiley   +1 more source

Psychosocial Syndemic of suicidal ideation: a cross-sectional study among sexually transmitted infection patients in Shanghai, China

BMC Public Health, 2020
Background Patients with sexually transmitted infections (STIs) experience difficulties with stability and trust in long-term relationships and have poor mental health, factors that may lead to suicidal ideation.
Suping Wang, Yang Ni, Ruijie Gong, Yuan Shi, Yong Cai, Jin Ma   +5 more
doaj   +1 more source

The prevalence of suicide ideation and predictive factors among pregnant women in the third trimester

BMC Pregnancy and Childbirth, 2022
Background Pregnancy is a period for women undergo major physical and psychological changes. Suicide is a cause of maternal death and suicidal ideation is a key factor in suicidal behavior.
Ling Zhang, Yating Yang, Mengdie Li, Xiaoqin Zhou, Kai Zhang, Xuai Yin, Huanzhong Liu   +6 more
doaj   +1 more source

Further Analyses of the Safety of Verubecestat in the Phase 3 EPOCH Trial of Mild-To-Moderate Alzheimer’s Disease [PDF]

, 2019
Background: Verubecestat, a BACE1 inhibitor that reduces Aβ levels in the cerebrospinal fluid of humans, was not effective in a phase 3 trial (EPOCH) of mild-to-moderate AD and was associated with adverse events.
Aisen, Paul S., Cummings, Jeffrey L., Egan, Michael F., Furtek, Christine, Kost, James, Lines, Christopher, Mahoney, Erin, Michaelson, David, Mukai, Yuki, Stone, Julie, Tariot, Pierre N., Vellas, Bruno, Voss, Tiffini   +12 more
core   +3 more sources

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

Prediction of suicidal ideation risk in a prospective cohort study of medical interns.

PLoS ONE, 2021
The purpose of this study was to identify individual and residency program factors associated with increased suicide risk, as measured by suicidal ideation.
Tyler L Malone, Zhou Zhao, Tzu-Ying Liu, Peter X K Song, Srijan Sen, Laura J Scott   +5 more
doaj   +1 more source