Results 41 to 50 of about 405,279 (308)

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source

The prevalence, course, and risk factors of suicidal ideation and suicide attempts among students in vocational education

Child and Adolescent Psychiatry and Mental Health
Background Worldwide, suicide is one of the leading causes of death among adolescents and young adults. Given that suicide in this age group is common within vocational students, this study aims to provide insights into the prevalence, course, and risk ...
Milou Looijmans, Paula von Spreckelsen, Guus Berkelmans, Arne Popma, Diana van Bergen, Renske Gilissen, Saskia Mérelle   +6 more
doaj   +1 more source

Second report of the suicide support and information system [PDF]

, 2013
National Office for Suicide Prevention (NOSP); Health Service Executive ...
Duggan, Aine, Wall, Amanda, Williamson, Eileen, McAuliffe, Carmel, McCarthy, Jacklyn, Perry, Ivan J, Arensman, Ella, Corcoran, Paul   +7 more
core   +1 more source

AfterWords: A survey of people bereaved by suicide in Ireland

, 2023
The specific objectives of this study were to: 1. Examine the profile, characteristics and wellbeing of adults bereaved or affected by suicide in Ireland 2. Determine the types of suicide bereavement supports accessed 3.
O'Connell, Selena, O'Brien, Cliodhna, Grennan, Adam, Daly, Caroline, Ruane-McAteer, Eimear, McDonnell, Laura, Griffin, Eve, Andriessen, Karl, Tuomey, Fiona, Arensman, Ella, Khan, Almas   +10 more
core  

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Best Practice Guidance for Suicide Prevention Services: Learning from development and early implementation

, 2021
This report summarises learning from evaluation activities carried out by the Centre for Effective Services (CES) in relation to the development and early implementation of the HSE National Office for Suicide Prevention (NOSP) Best Practice Guidance ...
Centre for Effective Services
core  

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Treating suicidality remotely (TREASURE): study protocol for a remote randomized controlled trial comparing personalized cognitive behavioral therapy for suicide prevention with a guided self-help course in adolescents and adults

Trials
Background Practical and psychological barriers make it difficult for people with Suicidal Thoughts and Behaviors (STBs) to obtain professional help. Remote interventions have the potential to overcome many of these barriers, but the remote interventions
Wilco Janssen, Saskia Mérelle, Renske Gilissen, Claudi Bockting   +3 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Testing the Integrated Motivational-Volitional Model of suicidal behavior in a young Danish population

BMC Psychiatry
Introduction The Integrated Motivational-Volitional model for suicidal behaviour (IMV-model) is a predominant model of suicide risk which was developed to enhance understanding of the emergence of suicidal thoughts and the transition from suicidal ...
Erik Christiansen, Agnieszka Konieczna, Christina Petrea Larsen, Sarah Grube Jakobsen, Rory C. O´Connor   +4 more
doaj   +1 more source