Results 81 to 90 of about 1,176,128 (395)

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

Advanced Science, EarlyView.
This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen, Ran Ren, Lirong Yan, Yu Zhou, Ruokai Sun, Huicong Song, Hongfei Yan, Yongsheng Li   +7 more
wiley   +1 more source

Cost-effectiveness of dialectical behaviour therapy vs. enhanced usual care in the treatment of adolescents with self-harm

Child and Adolescent Psychiatry and Mental Health, 2018
Background Studies have shown that dialectical behaviour therapy (DBT) is effective in reducing self-harm in adults and adolescents. Aims To evaluate the cost-effectiveness of DBT for adolescents (DBT-A) compared to enhanced usual care (EUC).
Egil Haga, Eline Aas, Berit Grøholt, Anita J. Tørmoen, Lars Mehlum   +4 more
doaj   +1 more source

Depression and suicide risk prediction models using blood-derived multi-omics data [PDF]

, 2019
More than 300 million people worldwide experience depression; annually, ~800,000 people die by suicide. Unfortunately, conventional interview-based diagnosis is insufficient to accurately predict a psychiatric status. We developed machine learning models
Bhak, Jong, Bhak, Youngjune, Blazyte, Asta, Cho, Juok, Cho, Yun Sung, Gim, Jeong-An, Ham, Byung-Joo, Jeon, Sungwon, Jeon, Yeonsu, Jeong, Hyoung-oh, Kang, Wooyoung, Kim, Aram, Kim, Byung Chul, Kim, Hak-Min, Kim, Yumi, Lee, Hae-Woo, Lee, Semin, Paik, Jong-Woo, Park, Seung Gu, Shin, Eun-Seok   +19 more
core   +1 more source

Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics

Advanced Science, EarlyView.
Muralidharan and colleagues develop cell‐type‐specific transcriptomic aging clocks using single‐nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict age and identify distinct aging trajectories in specific brain cell types.
Chandramouli Muralidharan, Enikő Zakar‐Polyák, Anita Adami, Anna A. Abbas, Yogita Sharma, Raquel Garza, Jenny G. Johansson, Diahann A. M. Atacho, Éva Renner, Miklós Palkovits, Csaba Kerepesi, Johan Jakobsson, Karolina Pircs   +12 more
wiley   +1 more source

Engineering Bacteria as Living Therapeutics in Cancer Therapy

Advanced Science, EarlyView.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai   +6 more
wiley   +1 more source

Adaptation of evidence‐based suicide prevention strategies during and after the COVID‐19 pandemic

World Psychiatry, 2020
Suicide is preventable. Nevertheless, each year 800,000 people die of suicide in the world. While there is evidence indicating that suicide rates de‐crease during times of crises, they are expected to increase once the immediate crisis has passed.
D. Wasserman, M. Iosue, A. Wuestefeld, V. Carli   +3 more
semanticscholar   +1 more source

Adolescent suicide and suicidal behavior [PDF]

Journal of Child Psychology and Psychiatry, 2006
This review examines the descriptive epidemiology, and risk and protective factors for youth suicide and suicidal behavior. A model of youth suicidal behavior is articulated, whereby suicidal behavior ensues as a result of an interaction of socio‐cultural, developmental, psychiatric, psychological, and family‐environmental factors. On the basis of this
David A. Brent, Jeffrey A. Bridge, Tina R. Goldstein   +2 more
openaire   +2 more sources

Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives

Advanced Science, EarlyView.
Micro/nanorobots (MNRs) offer a transformative approach for precision therapy in brain disorders. By overcoming biological barriers and enabling controlled propulsion, targeted delivery, and real‐time imaging/tracking, MNRs pave the way toward effective, minimally invasive treatments. This review outlines the interplay between brain disease challenges,
Qi Zhang, Dong Sun
wiley   +1 more source

Mediating Effects of Positive Thinking and Social Support on Suicide Resilience [PDF]

, 2018
Suicide has been the second leading cause of death for 18- to 24-year-olds in the United States since 2011. The stress experienced by undergraduate college students has the potential to increase one’s risk for suicide.
Bekhet, Abir K., Garnier-Villarreal, Mauricio, Matel-Anderson, Denise M.   +2 more
core   +1 more source

Current Developments and Challenges in the Field of Biohybrid Neural Interfaces—A Scoping Review

Advanced Electronic Materials, EarlyView.
This scoping review explores recent advancements and persistent challenges in biohybrid neural interfaces, which integrate living cells with electronic devices to improve neural communication and implant biocompatibility. The article highlights key innovations, methodological diversity, and translational barriers, providing a comprehensive synthesis ...
Yi‐Lin Yu, Jameel Muzaffar, Veronica Philips, Yun‐Ju Yang, Damiano Giuseppe Barone, George G. Malliaras, Manohar Bance   +6 more
wiley   +1 more source