Results 81 to 90 of about 1,000,995 (356)

Cost-effectiveness of dialectical behaviour therapy vs. enhanced usual care in the treatment of adolescents with self-harm

Child and Adolescent Psychiatry and Mental Health, 2018
Background Studies have shown that dialectical behaviour therapy (DBT) is effective in reducing self-harm in adults and adolescents. Aims To evaluate the cost-effectiveness of DBT for adolescents (DBT-A) compared to enhanced usual care (EUC).
Egil Haga, Eline Aas, Berit Grøholt, Anita J. Tørmoen, Lars Mehlum   +4 more
doaj   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Links Between Social Support, Thwarted Belongingness, and Suicide Ideation among Lesbian, Gay, and Bisexual College Students [PDF]

, 2017
Emerging adults with a lesbian, gay, or bisexual (LGB) identity are at greater risk for engaging in suicide-related behaviors. This disparity highlights a need to elucidate specific risk and protective factors associated with suicide-related behaviors ...
Hill, Ryan M, Kaplow, Julie B, Mooney, Megan A, Rooney, Evan E   +3 more
core   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Gendered endings: Narratives of male and female suicides in the South African Lowveld [PDF]

, 2012
This is the author's accepted manuscript. The final publication is available at Springer via http://dx.doi.org/10.1007/s11013-012-9258-y. Copyright @ Springer Science+Business Media, LLC 2012.Durkheim’s classical theory of suicide rates being a negative ...
Adam Kuper, Arnold Cooper, Brenda Farnell, Chris De Wet, Cluny MacPherson, D. Wassenaar, David Gilmore, David Riches, Dorothy Ayers Counts, Douglas Hollan, Edward Lipuma, Edwin Shneidman, Emanual Marx, Fatima Meer, Francis Hezel, Fraser McNeill, Henrietta Moore, Isak Niehaus, J. Van Winkle, Jack Douglas, James H. Chaplin, Kenneth Burke, Kristi Stølen, Liisa Malkki, M.D.W. Jeffreys, Margaret Gilmore, Marylin Strathern, Michael Kral, Michael Kral, Peter Carstens, Pierre Bourdieu, R. Matzopoulos, Raymond Firth, Ronald Littlewood, Roy F. Baumeister, South African Institute of Race Relations (SAIRR), W.D. Hammond-Tooke, Wendy James, Wim Van Binsbergen   +38 more
core   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

The use of social media after bereavement by suicide: results from a French online survey

BMC Psychiatry
Background According to recent research, the Internet and social media are shaping and changing how we die and mourn. However, the use of social media after bereavement by suicide remains poorly understood.
Edouard Leaune, Héloïse Rouzé, Laurène Lestienne, Kushtrim Bislimi, Margot Morgiève, Benoit Chalancon, Pauline Lau-Taï, Guillaume Vaiva, Pierre Grandgenèvre, Julie Haesebaert, Emmanuel Poulet   +10 more
doaj   +1 more source

Risk factors for suicidal ideation among survivors of suicide loss using a psychological support hotline

Frontiers in Psychiatry
IntroductionSuicide of a loved one significantly affects the physical and mental well-being of close friends and family members, potentially escalating to suicidal ideation in severe cases.
Hong Liang, Hong Liang, Zikang Liu, Zikang Liu, Zikang Liu, Xingxue Li, Xingxue Li, Xingxue Li, Jing An, Jing An, Liting Zhao, Liting Zhao, Lin Chen   +12 more
doaj   +1 more source

Suicidal deaths in elementary school students in Korea

Child and Adolescent Psychiatry and Mental Health, 2017
Background The purpose of this study was to determine the characteristics of childhood suicidal deaths among elementary school students that occurred from 2011 to 2015 in Korea. Methods The report form of each suicide case by the teacher in charge to the
Minha Hong, Han Nah Cho, Ah Reum Kim, Hyun Ju Hong, Yong-Sil Kweon   +4 more
doaj   +1 more source

Incidence of suicide and self-harm among people with opioid use disorder and the impact of opioid agonist treatment: A retrospective data linkage study [PDF]

, 2023
Samantha Colledge‐Frisby, N. R. Jones, Louisa Degenhardt, Matthew Hickman, Prianka Padmanathan, Thomas Santo, Michael Farrell, Natasa Gisev   +7 more
openalex   +1 more source